Take an EXTRA 25% OFF any initial
Program purchase — limited time only!

Shop our products & programs

• Doctor-formulated
• Natural & effective
• 100% guaranteed
• Made in FDA-inspected labs

Just $29.95

Add to Cart
T-Balance

T-Balance Plus

T-Balance Plus

Get fast, natural relief from the symptoms of underactive or low thyroid:

Average product rating: 
| 94% recommend T-Balance

  • Relieves symptoms – including fatigue, lack of energy, weight gain, fuzzy thinking, hair loss and sensitivity to cold
  • Restores thyroid balance and supports healthy thyroid function
  • Contributes to stable moods and mitigates mild depression
  • Helps holistically harmonize the thyroid with the body’s overall endocrine system
  • Ensures adequate iodine, a nutrient that when deficient can trigger thyroid problems

Join the 81% of women who report significant symptom relief with our alternative approach, most in less than 30 days. Our exclusive herbal formula is safe, bioavailable, manufactured to the FDA’s highest standards, and importantly, based on the latest science. Try T-Balance Plus today and say goodbye to your symptoms forever!

Our guarantee

"I feel much better and have a lot more energy. My hair has stopped falling out. I noticed a difference within a week."

— Sonia, USA*

What is T-Balance Plus?

T-Balance Plus is a completely natural herbal remedy that provides gentle relief for underactive thyroid or low thyroid.

Formulated to relieve the most common symptoms including loss of energy, hair loss, weight gain, fuzzy thinking, skin changes and sensitivity to cold temperatures, T-Balance Plus is based in the latest research on phytotherapy (plant-based medicine) to help create optimal levels of your thyroid hormones to eliminate symptoms without the risk of serious side effects.

T-Balance Plus includes the following powerful ingredients:

  • Bacopa monnieri — may help address fuzzy thinking and forgetfulness.
  • Hops — extracts have actions that allow thyroid hormones to enter cells more easily.
  • Sage — this herb has anti-inflammatory and antioxidant effects, with phytochemicals that support improved mood, memory, and healthy blood sugar balance.
  • Ashwagandha — widely used for its anti-stress and calming properties, it supports production of thyroid hormones.
  • Coleus forskohlii — mimics the effect of thyroid-stimulating hormone to enhance iodine uptake and thyroid hormone production. Studies show it has supportive effects on the immune system, body weight and for depression.
  • Iodine — this potent antioxidant synthesizes thyroid hormones and is needed for optimal function of every organ and cell in the body.
  • Selenium — necessary to regulate thyroid function and iodine metabolism.

Women rely on T-Balance Plus to help them feel and look the way they want without the need to go on prescription medication for the rest of their lives.

What is underactive or low thyroid?

What is subclinical hypothyroidism?

Subclinical hypothyroidism is a term that refers to abnormally low thyroid function when TSH (thyroid-stimulating hormone) is slightly high or almost high, but blood levels of thyroid hormones are normal. This state may not be considered a problem by conventional medical tests and as a result, remains undiagnosed.

Low thyroid function affects millions of Americans. Statistics strongly suggest that low or sluggish thyroid affects 6 times as many women as men and undiagnosed thyroid issues are extremely more common.

The hormones of the thyroid, thyroxine (T4) and triiodothyronine (T3) influence the metabolism of each and every cell in our bodies. Because of this, your thyroid helps determine how you metabolize food, how you store and use energy, how you think, talk, sleep and more. When your thyroid isn’t working correctly, all of these functions of your body can be affected.

With low thyroid function, your body may not be producing enough thyroid hormones or may have difficulty converting them into the active form your body uses.

Common symptoms of low thyroid function

  • Severe fatigue
  • Weight gain
  • Dry skin, brittle nails
  • Brittle hair
  • Itchy scalp
  • Hair loss
  • Sensitivity to cold
  • Lower body temperature
  • Low libido
  • Puffiness in face and extremities

Lesser-known symptoms of low thyroid function

  • Yellowing of palms & soles of feet
  • Joint & muscle pain
  • Depression
  • Digestive issues
  • PMS, menstrual irregularities
  • Hoarseness
  • Bruising/clotting problems
  • Elevated levels of LDL ("bad" cholesterol)
  • Allergies that suddenly appear or get worse
  • Persistent cold sores, boils or breakouts
  • Tingling sensation in wrist/hands
  • Memory loss
  • Fuzzy thinking
  • Slowness or slurring of speech
  • Appearance of a goiter

How do you know if you have low thyroid function?

Recognizing your own symptoms is important to determining if you have a thyroid issue. Because low thyroid function shares symptoms with many other endocrine disorders, looking for patterns of the most common symptoms — and a few of the lesser-known ones— will help you pinpoint whether your thyroid could be the cause.

Often the “normal” lab ranges for thyroid function used in conventional medicine are not able to identify thyroid problems, especially low thyroid. As a result, your doctor may say your thyroid test results are normal even when you are experiencing symptoms. A functional medicine practitioner may offer a different perspective on your medical tests.

The natural way to feel better

Phytotherapy or plant-based medicine is highly effective for relieving the symptoms of low thyroid function when the herbs are adaptogenic. Adaptogenic herbs have the power to adapt to the specific needs of your body. This is very different from the traditional “one-size-fits-all” approach many women encounter at the doctor’s office, which often includes a focus on prescription medication for thyroid issues.

Certain herbs known as phytocrines share important features with natural hormones, allowing them to provide symptom relief, and increase the body’s natural ability to make and use hormones:

  • Phytocrines can act like the body’s own hormones. By binding to our hormone receptors, they allow cells to get the information they need to function properly.
  • Phytocrines can imitate hormone functions. Certain phytocrines can mimic one or more functions of a hormone. For example, Bacopa monnieri mimics the abilities of estrogen to help the body adapt to chronic stress as well as maintain cognitive function.
  • Phytocrines encourage hormone production. Plants can gently stimulate the body’s tissues to make more natural hormones.

Reference:

Collins, J. Winter, 2006. Phytotherapeutic management of endocrine dysfunctions. NutriNews, pp. 1–4, 6–8. URL: http://www.douglaslabs.com/pdf/nutrinews%5CEndocrine%20Dysfunctions.pdf (accessed 12.19.2007).

*took T-Balance Plus as part of the Women’s Health Network Thyroid Program



Product References

Our T-Balance Plus is doctor-formulated to be complete, natural, bioavailable, and manufactured to pharmaceutical standards.

The following articles and studies, arranged in order of recency, represent a sampling of the research on the constituents of T-Balance Plus.

Ashwagandha (Withania somnifera/W. ashwagandha)

C Alam, N., et al. 2011. High catechin concentrations detected in Withania somnifera (ashwagandha) by high performance liquid chromatography analysis. BMC Complement. Altern. Med., 11, 65. URL: http://www.biomedcentral.com/1472-6882/11/65 (accessed 09.23.2011).

C Kumar, A., et al. 2011. Utility of a multidisciplinary approach for genome diagnostics of cultivated and wild germplasm resources of medicinal Withania somnifera, and the status of new species, W. ashwagandha, in the cultivated taxon URL: http://www.springerlink.com/content/g12001h123tk2876/ (accessed 09.06.2011).

C Sinha, S., et al. 2011. In vivo anti-tussive activity and structural features of a polysaccharide fraction from water extracted Withania somnifera. J Ethnopharmacol. 2011 Mar 24;134 (2), 510-513. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21182915 (accessed 09.23.2011).

C Dog, T. 2010. Smart Talk on supplements and botanicals: Ginseng and other adaptogenic herbs. Alt. Complement. Ther., 16 (1), 1–4. URL (paid access): http://www.liebertonline.com/doi/abs/10.1089/act.2010.16101 (accessed 01.17.2011).

C Ven Murthy, M., et al. 2010. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: Ashwagandha. Cent. Nerv. Syst. Agents Med. Chem., 10 (3), 238-246. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20528765 (accessed 09.23.2011).

C Yadav, B., et al. 2010. In vitro anticancer activity of the root, stem and leaves of Withania somnifera against various human cancer cell lines. Indian J. Pharm. Sci., 72 (5), 659-663. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116319/?tool=pubmed (accessed 09.23.2011).

C Cooley, K., et al. 2009. Naturopathic care for anxiety: A randomized controlled trial ISRCTN78958974. PLoS One, 4 (8), e6628. URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006628 (accessed 05.13.2011).

A1–A3, A5, B, C Collins, J. 2007. Phytotherapeutic support of thyroid function. NutriNews. URL (PDF): http://www.douglaslabs.com/pdf/nutrinews/Thyroid%20Function%20Support%20%2801-07%29.pdf (accessed 08.10.2010).

B, C Widido, N., et al. 2007. Selective killing of cancer cells by leaf extract of Ashwagandha: Identification of a tumor-inhibitory factor and the first molecular insights to its effect. Clin. Cancer Res., 13 (7), 2298–2306. URL: http://clincancerres.aacrjournals.org/content/13/7/2298.long (accessed 02.23.2011).

C Naidu, P., et al. 2006. Effect of Withania somnifera root extract on reserpine-induced orofacial dyskinesia and cognitive dysfunction. Phytother. Res., 20 (2), 140–146. URL: http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0706122/full (accessed 02.23.2011).

B Winters, M. 2006. Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern. Med. Rev., 11 (4), 269-277. URL (PDF): http://www.altmedrev.com/publications/11/4/269.pdf (accessed 09.23.2011).

C Kuboyama, T., et al. 2005. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br. J. Pharmacol., 144 (7), 961–971. URL: http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0706122/full (accessed 02.23.2011).

C Misra, L., et al. 2005. Unusually sulfated and oxygenated steroids from Withania somnifera. Phytochemistry, 66, 2702–2707. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16293277 (accessed 02.23.2011).

A1–A3, A5 [No authors listed.] 2004. Monograph. Withania somnifera. Altern. Med. Rev., 9 (2), 211–214. URL: http://www.thorne.com/altmedrev/.fulltext/9/2/211.pdf (accessed 02.23.2011).

C Sreerekha, M., et al. 2004. Distribution of total withanolides in various plant parts of Ashwagandha (Withania somnifera) accessions as influenced by light and dark reaction cycle. J. Med. Aromatic Plant Sci., 26, 681–683. URL (abstract): http://203.190.147.122/jmapsnew/JMAPSDisplay.aspx?Year=2004&Month=12&Volume=26&No=4&IssueID=338 (accessed 09.06.2011).

C Bhattacharya, S., & Muruganandam, A. 2003. Adaptogenic activity of Withania somnifera: An experimental study using a rat model of chronic stress. Pharmacol. Biochem. Behav., 75 (3), 547–555. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12895672 (accessed 02.23.2011).

C Iuvone, T., et al. 2003. Induction of nitric oxide synthase expression by Withania somnifera macrophages. Life Sci., 72 (14), 1617-1625. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12551750 (accessed 01.25.2011).

B, C Singh, G., et al. 2003. Adaptogenic activity of a novel, withanolide-free aqueous fraction from the roots of Withania somnifera Dun. (Part II). Phytother. Res., 17 (3), 531–536. URL: http://www.ncbi.nlm.nih.gov/pubmed/12748992 (accessed 02.24.2011).

C Dhuley, J. 2001. Nootropic-like effect of Ashwagandha (Withania somnifera L.) in mice. Phytother Res., 15 (6), 524–528. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11536383 (accessed 02.23.2011).

C Jain, S., et al. 2001. Neuroprotective effects of Withania somnifera Dunn. in hippocampal sub-regions of female albino rat. Phytother. Res., 15 (6), 544–548. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11536389 (accessed 02.23.2011).

B, C Singh, G., et al. 2001. Adaptogenic activity of a novel, withanolide-free aqueous fraction from the roots of Withania somnifera Dun. Phytother. Res., 15 (4), 311–318. URL: http://www.ncbi.nlm.nih.gov/pubmed/11406854 (accessed 02.24.2011).

B, C Andallu, B. & Radhika, B. 2000. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J. Exp. Biol., 38 (6), 607-609. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11116534 (accessed 05.13.2011).

C Battacharya, S., et al. 2000. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: An experimental study. Phytomedicine, 7 (6), 463–469. URL: http://www.ncbi.nlm.nih.gov/pubmed/11194174 (accessed 01.25.2011).

B, C Dhuley, J. 2000. Adaptogenic and cardioprotective action of ashwagandha in rats and frogs. J. Ethnopharmacol., 70 (1), 57–63. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/10720789 (accessed 02.23.2011).

A1–A5, B, C Mishra, L-C., et al. 2000. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): A review. Altern. Med. Rev., 5 (4), 334–346. URL (PDF): http://www.thorne.com/altmedrev/.fulltext/5/4/334.pdf (accessed 02.23.2011).

C Archana, R., & Namasivayam, A. 1999. Antistressor effect of Withania somnifera. J. Ethnopharmcol., 64 (1), 91–93. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/10075127 (accessed 01.26.2011).

A1–A3, A5 Panda, S., & Kar, A. 1999. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J. Ethnopharmacol., 67 (2), 233-239. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/10619390 (accessed 10.04.2011).

B, C Rege, N.-N., et al. 1999. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res., 13 (4), 275–291. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/10404532 (accessed 02.23.2011).

C Aphale, A., et al. 1998. Subacute toxicity study of the combination of ginseng (Panax ginseng) and ashwagandha (Withania somnifera) in rats: A safety assessment. Indian J. Physiol. Pharmacol., 42 (2), 299-302. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/10225062 (accessed 05.13.2011).

A1–A3, A5, C Panda, S., & Kar, A. 1998. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J. Pharm. Pharmacol., 50 (9), 1065-1068. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/9811169 (accessed 10.04.2011).

C Schauss, A., et al. 1998. Therapeutic applications of Withania somnifera (Ashwagandha) — popular ayurvedic botanical medicine. Nat. Med. J., 1 (10), 16–19.

C Schliebs, R., et al. 1997. Systemic administration of defined extracts from Withania somnifera (Indian Ginseng) and Shilajit differentially affects cholinergic but not glutamatergic and GABAnergic markers in rat brain. Neurochem. Int., 30 (2), 181–190. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/9017665 (accessed 02.23.2011).

C al-Hindawi, M., et al. 1992. Anti-granuloma activity of Iraqi Withania somnifera. J. Ethnopharmacol., 37 (2), 113–116. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/1434685 (accessed 02.23.2011).

C Mehta, A., et al. 1991. Pharmacologic effects of Withania somnifera root extract on GABAA receptor complex. Indian J. Med. Res., 94, 312–315. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/1660034 (accessed 02.23.2011).

A1–A3, A5 Köhrle, J., et al. 1988. Flavonoid effects on transport, metabolism and action of thyroid hormones. Prog. Clin. Biol. Res., 280, 323-340. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/3140249 (accessed 10.04.2011).

C Singh, N., et al. 1982. Withania somnifera (ashwagandha), a rejuvenating herbal drug which enhances survival during stress (an adaptogen). Int. J. Crude Drug Res., 20 (1), 29–35. URL (abstract): http://informahealthcare.com/doi/abs/10.3109/13880208209083282 (accesesd 10.05.2011).

Bacopa monnieri (water hyssop)

C Abascal, K., & Yarnell, E. 2011. Bacopa for the brain: A smart addition to Western medicine. Altern. Complement. Ther., 17 (1), 21-25. URL (abstract): http://www.deepdyve.com/lp/mary-ann-liebert/bacopa-for-the-brain-a-smart-addition-to-western-medicine-xPGtuo07v0 (accessed 09.29.2011).

C Bhaskar, M., & Jagtap, A. 2011. Exploring the possible mechanisms of action behind the antinociceptive activity of Bacopa monniera. Int. J. Ayurveda Res., 2 (1), 2-7. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157104/?tool=pubmed (accessed 09.29.2011).

B Oliff, H. 2011. RE: Review of clinical potential of Bacopa in treatment of central nervous system-related ailments. HerbClip. URL (PDF): http://cms.herbalgram.org/herbclip/430/pdfs/041157.pdf (accessed 09. 29.2011).

B, C Morgan, A., & Stevens, J. 2010. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J. Altern. Complement. Med., 16 (7), 753–759. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20590480 (accessed 09.28.2011).

C Sumathi, T., & Niranjali Devaraj, S. 2009. Effect of Bacopa monnierai on liver and kidney toxicity in chronic use of opioids. Phytomedicine, 16 (10), 897-903. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19403290 (accessed 05.16.2011).

B, C Calabrese, C., et al. 2008. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: A randomized, double-blind, placebo-controlled trial. J. Altern. Complement Med., 14 (6), 707-713. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153866/?tool=pubmed (accessed 05.16.2011).

A1–A3, A5, B, C Collins, J. 2007. Phytotherapeutic support of thyroid function. NutriNews. URL (PDF): http://www.douglaslabs.com/pdf/nutrinews/Thyroid%20Function%20Support%20%2801-07%29.pdf (accessed 08.10.2010).

C Stough, C., et al. 2008. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90-day double-blind placebo-controlled randomized trial. Phytother Res., 22 (12), 1629–1634. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18683852 (accessed 09.28.2011).

B, C Pravina, K., et al. 2007. Safety evaluation of BacoMind in healthy volunteers: A phase I study. Phytomedicine, 14 (5), 301–308. URL: http://www.sciencedirect.com/science/article/pii/S0944711307000487 (accessed 10.05.2011).

B, C Raghav, S., et al. 2006. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J. Psychiatry, 48 (4), 238-242. URL: http://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2006;volume=48;issue=4;spage=238;epage=242;aulast=Raghav (accessed 05.16.2011).

C Russo, A., & Borrelli, F. 2005. Bacopa monniera, a reputed nootropic plant: An overview. Phytomedicine, 12 (4), 305–317. URL: http://www.thefreelibrary.com/Bacopa+monniera%2c+a+reputed+nootropic+plant%3a+an+overview-a0133802203 (accessed 09.29.2011).

A1–A3, A5 Kar, A., et al. 2002. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J. Ethnopharmacol., 81 (2), 281–285. URL (abstract): http://www.sciencedirect.com/science/article/pii/S037887410200048X (accessed 10.05.2011).

C Sairam, K., et al. 2002. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine, 9 (3), 207–211. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12046860 (accessed 09.29.2011).

B Asthana, O., et al. 1996. Safety and tolerability of bacosides A and B in healthy human volunteers. Indian J. Pharmacol., 28 (1), 37. URL (no abstract available): http://indianmedicine.eldoc.ub.rug.nl/root/A/2065/ (accessed 10.05.2011).

Coleus forskohlii

A1–A3, A5, C Andrade, B., et al. 2011. A novel role for AMP-kinase in the regulation of the Na+/I--symporter and iodide uptake in the rat thyroid gland. Am. J. Physiol. Cell. Physiol,, 300 (6), C1291-1297. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21389275 (accessed 10.06.2011).

C Doorn, J., et al. 2011. Forskolin enhances in vivo bone formation by human mesenchymal stromal cells. Tissue Eng. Part A. [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21942968 (accessed 10.06.2011).

B Montalbetti, N., et al. 2011. Homeostasis of extracellular ATP in human erythrocytes. J. Biol. Chem. [Epub ahead of print.] URL: http://www.jbc.org/content/early/2011/09/15/jbc.M111.221713.long (accessed 10.06.2011).

C Lele, R. 2010. Beyond reverse pharmacology: Mechanism-based screening of Ayurvedic drugs. J. Ayurveda Integr. Med., 1 (4), 257–265. URL: http://www.jaim.in/article.asp?issn=0975-9476;year=2010;volume=1;issue=4;spage=257;epage=265;aulast=Lele (accessed 10.06.2011).

C Lichtl–Kaiser, K., et al. 2009. Cyclic AMP-dependent protein kinase signaling modulates pregnane x receptor activity in a species-specific manner. J. Biol. Chem., 284 (11), 6639–6649. URL (PDF): http://www.jbc.org/content/284/11/6639.full.pdf+html (accessed 10.05.2011).

A1–A3, A5, B, C Ding, X, & Staudinger, J. 2005. Induction of drug metabolism by forskolin: The role of the pregnane X receptor and the protein kinase A signal transduction pathway. JPET, 312 (2), 849–856. URL: http://jpet.aspetjournals.org/content/312/2/849.long (accessed 10.05.2011).

A1–A3, A5, C Sun, S-C., et al. 2009. Thyrostimulin, but not thyroid-stimulating hormone (TSH), acts as a paracrine regulator to activate the TSH receptor in mammalian ovary. J. Biol. Chem., 285 (6), 3758 –3765. URL: http://www.jbc.org/content/285/6/3758.long (accessed 10.06.2011).

A1–A3, A5, B, C Collins, J. 2007. Phytotherapeutic support of thyroid function. NutriNews. URL (PDF): http://www.douglaslabs.com/pdf/nutrinews/Thyroid%20Function%20Support%20%2801-07%29.pdf (accessed 08.10.2010).

A1–A3, A5, B, C Monograph. 2006. Coleus forskohlii. Altern. Med. Rev. 11 (1), 47-51. URL: http://www.altmedrev.com/publications/11/1/47.pdf (accessed 05.16.2011).

B, C Henderson, S., et al. 2005. Effects of Coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. J. Int. Soc. Sports Nutr., 2 (2), 54-64. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129145/ (accessed 05.16.2011).

A1–A5 Venkateswaran, A., et al. 2004. Forskolin, 8-Br-3',5'-cyclic adenosine 5'-monophosphate, and catalytic protein kinase A expression in the nucleus increase radioiodide uptake and sodium/iodide symporter protein levels in RET/PTC1-expressing cells. J. Clin. Endocrinol. Metab., 89 (12), 6168-6172. URL: http://jcem.endojournals.org/content/89/12/6168.long (accessed 10.06.2011).

C Sidhu, J., & Omiecinski, C. 1996. Forskolin-mediated induction of CYP3A1 mRNA expression in primary rat hepatocytes is independent of elevated intracellular cyclic AMP. J. Pharmacol. Exp. Ther., 276 (1), 238–245. URL: http://jpet.aspetjournals.org/content/276/1/238.abstract?ijkey=219ddd03765d3387d7e844b1c078e2a82694c2d5&keytype2=tf_ipsecsha (accessed 10.05.2011).

A1–A3. A5, C Roger, P., et al. 1987. Regulation of dog thyroid epithelial cell cycle by forskolin, and adenylate cyclase activator. Exp. Cell. Res., 172 (2), 282-292. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/2820768 (accessed 10.06.2011).

C Ammon, H., & Muller, A. 1985. Forskolin: From an ayurvedic remedy to a modern agent. Planta Med. 51, 473-477. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/17345261 (accessed 10.06.2011).

A1–A3, A5, C Haye, B., et al. 1985. Chronic and acute effects of forskolin on isolated thyroid cell metabolism. Mol. Cell Endocrinol., 43 (1), 41-50. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/2998908 (accessed 10.06.2011).

A1–A3, A5, C Kasai, K., et al. 1985. Forskolin stimulation of adenylate cyclase in human thyroid membranes. Acta Endocrinol. (Copenh.), 108 (2), 200-205. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/4038568 (accessed 10.06.2011).

C Mokhtari, A., et al. 1985. Forskolin modulates cyclic AMP generation in the rat myometrium. Interactions with isoproterenol and prostaglandins E2 and I2. J. Cyclic Nucleotide Protein Phosphor. Res., 10 (3), 213-227. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/2991348 (accessed 10.06.2011).

C Daly, J., et al. 1982. Activation of cyclic AMP-generating systems in brain membranes and slices by the diterpene forskolin: augmentation of receptor-mediated responses. J. Neurochem., 38 (2), 532-544. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/6125572 (accessed 10.06.2011).

A1–A5, C Fradkin J., et al. 1982. Forskolin stimulation of thyroid adenylate cyclase and cyclic 3',5'-adenosine monophosphate accumulation. Endocrinology, 111 (3), 849-856. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/6286284 (accessed 10.06.2011).

C Seamon, K., & Daly, J. 1981. Forskolin: A unique diterpene activator of cyclic AMP-generating systems. J. Cyclic Nucleotide Res., 7 (4), 201-224. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/6278005 (accessed 10.06.2011).

A4, C Seamon, K., et al. 1981. Forskolin: A unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc. Natl. Acad. Sci. USA, 78, 3363-3367. URL (abstract) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC319568/ (accessed 10.06.2011).

Humulus lupulus (hops)

B, C Dorn, C., et al. 2010. Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells. Int. J. Oncol., 36 (2), 435-441. URL: http://www.ncbi.nlm.nih.gov/pubmed/20043079 (accessed 10.06.2011).

B Dorn, C., et al. 2010. Xanthohumol feeding does not impair organ function and homoeostasis in mice. Food Chem. Toxicol., 48 (7), 1890-1897. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20427021 (accessed 10.06.2011).

A1–A3, A5, C Radovic, B., et al. 2010. Xanthohumol, a prenylated chalcone from hops, modulates hepatic expression of genes involved in thyroid hormone distribution and metabolism. Mol. Nutr. Food Res., 54 (Suppl. 2), S225-S235. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20461738 (accessed 10.06.2011).

B, C Ho, Y-C., et al. 2008. Inhibitory effects of xanthohumol from hops (Humulus lupulus L.) on human hepatocellular carcinoma cell lines. Phytother. Res., 22 (11), 1465-1468. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18814205 (accessed 10.06.2011).

C Zanoli, P., & Zavatti, M. 2008. Pharmacognostic and pharmacological profile of Humulus lupulus L. J. Ethnopharmacol., 116 (3), 383–396. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18308492 (accessed 10.06.2011).

A1–A3, A5, B, C Collins, J. 2007. Phytotherapeutic support of thyroid function. NutriNews. URL (PDF): http://www.douglaslabs.com/pdf/nutrinews/Thyroid%20Function%20Support%20%2801-07%29.pdf (accessed 08.10.2010).

B Nagasako-Akazome, Y., et al. 2007. Safety evaluation of polyphenols extracted from hop bracts. Food Chem. Toxicol., 45 (8), 1383-1392. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/17376578 (accessed 04.16.2011).

C Delmulle, L., et al. 2006. Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines. Phytomedicine, 13 (9-10), 732-734. URL: http://www.ncbi.nlm.nih.gov/pubmed/16678392 (accessed 10.06.2011).

C Vanhoecke, B., et al. 2005. Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer. Int. J. Cancer, 117 (6), 889-895. URL: http://www.ncbi.nlm.nih.gov/pubmed/15986430 (accessed 10.06.2011).

B, C Morin, C., et al. 2005. Valerian-hops combination and diphenhydramine for treating insomnia: A randomized placebo-controlled clinical trial. Sleep, 28 (11), 1465-1471. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16335333 (accessed 05.16.2011).

C Nikolic, D., et al. 2005. Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes. J. Mass Spectrom., 40 (3), 289–299. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/15712367 (accessed 10.07.2011).

A1–A3, A5, C Radovic, B., et al. 2005. Xanthohumol stimulates iodide uptake in rat thyroid-derived FRTL-5 cells. Mol. Nutr. Food Res., 49 (9), 832-836. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16092068 (accessed 10.06.2011).

B, C Vanhoecke, B., et al. 2005. A safety study of oral tangeretin and xanthohumol administration to laboratory mice. In Vivo, 19 (1), 103-107. URL: http://iv.iiarjournals.org/content/19/1/103.long (accessed 10.06.2011).

C Stevens, J., & Page, J. 2004. Xanthohumol and related prenylflavonoids from hops and beer: To your good health! Phytochemistry, 65 (10), 1317–1330. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/15231405 (accessed 10.06.2011).

C Milligan, S., et al. 1999. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J. Clin. Endocrinol. Metab., 84 (6), 2249-2252. URL: http://jcem.endojournals.org/content/84/6/2249.long (accessed 10.06.2011).

C Stevens J., et al. 1999. Fate of xanthohumol and related prenylflavonoids from hops to beer. J. Agric. Food Chem., 47, 2421-2428. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/10794646 (accessed 10.06.2011).

B, C Schmitz, M., & Jäckel, M. 1998. Comparative study for assessing quality of life of patients with exogenous sleep disorders (temporary sleep onset and sleep interruption disorders) treated with a hops-valerian preparation and a benzodiazepine drug. Wien. Med. Wochenschr., 148 (13), 291-298. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/9757514 (accessed 05.16.2011).

Iodine

C Dasgupta, P. 2009. Perchlorate: A cause for iodine deficiency? Environ. Chem., 6 (1), 7–9. URL (abstract): http://www.publish.csiro.au/nid/188/paper/EN08108.htm (accessed 06.15.2009).

A1–A5, B, C Zimmermann, M. 2009. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: A review. Am. J.Clin. Nutr., 89 (2), 668S–672S. URL (abstract): http://www.ajcn.org/content/89/2/668S.long (accessed 06.12.2009).

A1–A5, B, C Brownstein, D. 2008. Iodine: Why you need it. Why you can’t live without it, 104. West Bloomfield, MI: Medical Alternatives Press.

B, C Dasgupta, P., et al. 2008. Iodine nutrition: Iodine content of iodized salt in the United States. Environ. Sci. Technol., 42 (4), 1315–1323. URL (PDF): http://pubs.acs.org/doi/pdfplus/10.1021/es0719071 (accessed 05.15.2009).

A1, A2, A3, A5 Kopp, P. 2008. Reduce, recycle, reuse — Iodotyrosine deiodinase in thyroid iodide metabolism. NEJM, 358 (17), 1856–1859. URL: http://content.nejm.org/cgi/content/full/358/17/1856 (accessed 05.12.2009).

A1–A5, B, C Patrick, L. 2008. Iodine deficiency and therapeutic considerations. Alt. Med. Rev., 13 (2), 116–127. URL (PDF): http://www.thorne.com/altmedrev/.fulltext/13/2/116.pdf (accessed 06.12.2009).

A1–A3, A5, B, C Collins, J. 2007. Phytotherapeutic support of thyroid function. NutriNews. URL (PDF): http://www.douglaslabs.com/pdf/nutrinews/Thyroid%20Function%20Support%20%2801-07%29.pdf (accessed 08.10.2010).

B, C Hollowell, J., & Haddow, J. 2007. The prevalence of iodine deficiency in women of reproductive age in the United States. Public Health Nutr., 10 (12A), 1532–1539; discussion 1540–1541. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18053275 (accessed 06.15.2009).

C Blount, B., et al. 2006. Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States. Environ. Health Perspect., 114 (12), 1865–1871. URL: http://www.ehponline.org/members/2006/9466/9466.html (accessed 06.15.2009).

A1–A5, B, C Utiger, R. 2006. Iodine nutrition — more is better. NEJM, 354 (26), 2819–2821. URL: http://content.nejm.org/cgi/content/full/354/26/2819 (accessed 06.12.2009).

See also correction: NEJM, 355 (12), 1289. URL: http://content.nejm.org/cgi/content/full/355/12/1289 (accessed 06.12.2009).

C Caldwell, K., et al. 2005. Urinary iodine concentration: United States National Health and Nutrition Examination Survey 2001–2002. Thyroid, 15 (7), 692–699. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16053386 (accessed 06.15.2009).

A1–A5, B Angermayr, L., & Clar, C. 2004. Iodine supplementation for preventing iodine deficiency disorders in children. CDSR, 2, CD00819. URL (summary): http://www2.cochrane.org/reviews/en/ab003819.html (accessed 09.29.2011).

A1–A5, B, C de Benoist, B., et al., eds. 2004. Iodine status worldwide: WHO global database on iodine deficiency. Geneva: World Health Organization. URL (PDF): http://whqlibdoc.who.int/publications/2004/9241592001.pdf (accessed 06.11.2009).

B, C Hathcock, J. 2004. Iodine. In Vitamin and Mineral Safety, 2nd edition. Washington, DC: Council for Responsible Nutrition. URL (PDF): http://www.crnusa.org/safetypdfs/024CRNSafetyIodine.pdf (accessed 09.29.2011).

C Vermiglio, F., et al. 2004. Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild–moderate iodine deficiency: A possible novel iodine deficiency disorder in developed countries. Clin. Endocrinol. Metab., 89 (12), 60544–6060. URL: http://jcem.endojournals.org/cgi/content/full/89/12/6054 (accessed 06.16.2009).

B Wright, S. 2002. US iodine consumption declining. Boston Globe, July 22, 2002, page A3. URL: http://www.allthyroid.org/news/archive/iodine_deficiency.html (accessed 06.15.2009).

Food and Nutrition Board, Institute of Medicine. 2001. Dietary Reference Intakes, 258. Washington DC: National Academy Press.

A1–3, A5, B, C Hollowell, J., et al. 1998. Iodine nutrition in the United States. Trends and public health implications: Iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971–1974 and 1988–1994). J. Clin. Endocrinol. Metab., 83 (10), 3401–3408. URL: http://jcem.endojournals.org/cgi/content/full/83/10/3401 (accessed 06.12.2009).

A1–A5 Laurenberg, P., et al. 1998. Iodine intake and the pattern of thyroid disorders: A comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. J. Clin. Endocrinol. Metab., 83, 765–769. URL: http://jcem.endojournals.org/cgi/content/full/83/3/765 (accessed 05.19.2009).

A1–A5, B Reinhardt, W., et al. 1998. Effect of small doses of iodine on thyroid function in patients with Hashimoto’s thyroiditis residing in an area of mild iodine deficiency. Eur. J. Endocrinol., 139 (1), 23-28. URL: http://eje-online.org/content/139/1/23.long (accessed 09.29.2011).

A1–A5, B, C Stanbury, J. 1996. Iodine deficiency and iodine deficiency disorders. In E. Ziegler & L. Filer, eds. Present Knowledge of Nutrition, 7th ed., 378–383. Washington, DC: ILSI Press.

B Chow, C., et al. 1991. Effect of low-dose iodide supplementation on thyroid function in potentially susceptible subjects: Are dietary iodide levels in Britain acceptable? Clin. Endocrinol., 34 (5), 416–423. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/2060151 (accessed 09.29.2011).

A1, A2, A3, A5 Melish, J. 1990. Chapter 135. Thyroid Disease. In Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Walker, H., et al., eds. Boston: Butterworths. URL: http://www.ncbi.nlm.nih.gov/books/NBK241/ (accessed 09.29.2011).

Sage (Salvia officinalis)

B, C Bommer, S., et al. 2011. First time proof of sage’s tolerability and efficacy in menopausal women with hot flushes. Adv. Ther., 28 (6), 490-500. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21630133 (accessed 10.04.2011).

B, C Miguel, G., et al. 2011. Salvia officinalis L. essential oils: effect of hydrodistillation time on the chemical composition, antioxidant and antimicrobial activities. Nat. Prod. Res., 25 (5), 526-541. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21391115 (accessed 10.04.2011).

B, C Walch, S., et al. 2011. Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.). Chem. Cent. J., 5, 44. URL http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155476/?tool=pubmed (accessed 10.04.2011).

C Lamien-Meda, A., et al. 2010. Investigation of antioxidant and rosmarinic acid variation in the sage collection of the Genebank in Gatersleben. J. Agric. Food Chem., 58 (6), 3813-3819. URL (abstract): http://pubs.acs.org/doi/abs/10.1021/jf903993f (accessed 10.04.2011).

B Oniga, I., et al. 2010. Chemical composition of the essential oil of Salvia officinalis L. from Romania. Rev. Med. Chir. Soc. Med. Nat. Iasi., 114 (2), 593-595. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20701010 (accessed 10.04.2011).

C Oboh, G., & Henle, T. 2009. Antioxidant and inhibitory effects of aqueous extracts of Salvia officinalis leaves on pro-oxidant-induced lipid peroxidation in brain and liver in vitro. J. Med. Food., 12 (1), 77–84. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19298199 (accessed 10.04.2011).

B, C Schapowal, A., et al. 2009. Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: A randomized double-blind trial. Eur. J. Med. Res., 14 (9), 406-412. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19748859 (accessed 09.29.2011).

B Bozin, B., et al. 2007. Antimicrobial and antioxidant properties of rosemary and sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) essential oils. J. Agric. Food Chem., 55 (19), 7879-7885. URL (abstract): http://pubs.acs.org/doi/abs/10.1021/jf0715323 (accessed 10.04. 2011).

A1–A3, A5, B, C Collins, J. 2007. Phytotherapeutic support of thyroid function. NutriNews. URL (PDF): http://www.douglaslabs.com/pdf/nutrinews/Thyroid%20Function%20Support%20%2801-07%29.pdf (accessed 08.10.2010).

B Fecka, I., & Turek, S. 2007. Determination of water-soluble polyphenolic compounds in commercial herbal teas from Lamiaceae: Peppermint, melissa, and sage. J. Agric. Food Chem., 55 (26), 10908-10917. URL (abstract): http://pubs.acs.org/doi/abs/10.1021/jf072284d (accessed 10.04.2011).

B, C Raal, A., et al. 2007. Composition of the essential oil of Salvia officinalis L. from various European countries. Nat. Prod. Res., 21 (5), 406-411. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/17487611 (accessed 10.04.2011).

B, C Hubbert, M., et al. 2006. Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis — a randomised, double-blind, placebo-controlled study with adaptive design and interim analysis. Eur. J. Med. Res., 11 (1), 20-26. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16504956 (accessed 05.16.2011).

B, C Akhondzadeh, S., et al. 2003. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: A double blind, randomized and placebo-controlled trial. J. Clin. Pharm. Ther., 28 (1), 53-59. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12605619 (accessed 05.16.2011).

B, C Miura, K., et al. 2003. Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. J. AGric. Food Chem., 50 (7), 1845–1851. URL (abstract): http://pubs.acs.org/doi/abs/10.1021/jf011314o (accessed 10.04.2011).

A1–A3, A5, C Danilenko, M., et al. 2001. Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by other agents. J. Natl. Cancer Inst., 93 (16), 1224–1233. URL: http://jnci.oxfordjournals.org/content/93/16/1224.long (accessed 10.07.2011).

A1–A3, A5, C Steiner, M., et al. 2001. Carnosic acid inhibits proliferation and augments differentiation of human leukemic cells induced by 1,25-dihydroxyvitamin D3 and retinoic acid. Nutr Cancer, 41 (1-2), 135-44. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12094616 (accessed 10.07.2011).

C Zupkó, I., et al. 2001. Antioxidant activity of leaves of Salvia species in enzyme-dependent and enzyme-independent systems of lipid peroxidation and their phenolic constituents. Planta Med., 67 (4), 366-368. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11458459 (accessed 10.04.2011).

C Hohmann, J., et al. 1999. Protective effects of the aerial parts of Salvia officinalis, Melissa officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme-independent lipid peroxidation. Planta Med., 65 (6), 576-578. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/10532875 (accessed 10.04.2011).

B Perry, N., et al. 1999. Essential oils from Dalmatian sage (Salvia officinalis I.): Variations among individuals, plant parts, seasons, and sites. J. Agric. Food Chem., 47 (5), 2048–2054. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/10552494 (accessed 10.04.2011).

A1–A3, A5, B, C De Leo, V., et al. 1998. [Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent.] Minerva Ginecol., 50 (5), 207-211. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/9677811 (accessed 05.16.2011).

B, C Wang, M., et al. 1998. Antioxidative phenolic compounds from sage (Salvia officinalis). J. Agric. Food Chem., 46 (12), 4869–4873. URL (abstract): http://pubs.acs.org/doi/abs/10.1021/jf980614b (accessed 10.04.2011).

C Cuvelier, M., et al. 1994. Antioxidant constituents in sage (Salvia officinalis). J. Agric. Food Chem., 42 (3), 665–669. URL (abstract): http://pubs.acs.org/doi/abs/10.1021/jf00039a012 (accessed 10.04.2011).

Selenium

A1–3, A5 Kishosha, P., et al. 2011. Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. World. J. Surg., 35 (7), 1540–1545. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21523503 (accessed 09.30.2011).

A1–3, A5, B Marcocci, C., et al. 2011. NEJM, 364, 1920-1931. Selenium and the course of mild Graves’ orbitopathy URL: http://www.nejm.org/doi/full/10.1056/NEJMoa1012985 (accessed 08.25.2011).

C Combs, G., et al. 2009. Effects of selenomethionine supplementation on selenium status and thyroid hormone concentrations in healthy adults. Am. J. Clin. Nutr., 89 (6), 1808–1814. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682996/?tool=pubmed (accessed 09.30.2011).

B, C Schrauzer, G., & Surai, P. 2009. Selenium in human and animal nutrition: Resolved and unresolved issues. A partly historical treatise in commemoration of the fiftieth anniversary of the discovery of the biological essentiality of selenium, dedicated to the memory of Klaus Schwarz (1914-1978) on the occasion of the thirtieth anniversary of his death. Crit. Rev. Biotechnol., 29 (1), 2-9. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19514898 (accessed 10.04.2011).

A1–A3, A5, B Patrick, L. 2008. Iodine deficiency and therapeutic considerations. Alt. Med. Rev., 13 (2), 116–127. URL (PDF): http://www.thorne.com/altmedrev/.fulltext/13/2/116.pdf (accessed 06.12.2009).

A1–A3, B Rayman, M., et al. 2008. Randomized controlled trial of the effect of selenium supplementation on thyroid function in the elderly in the United Kingdom. Am. J. Clin. Nutr., 87 (2), 370–378. URL: http://www.ajcn.org/content/87/2/370.long (accessed 09.30.2011).

C Reid, M., et al. 2008. The nutritional prevention of cancer: 400 mcg per day selenium treatment. Nutr. Cancer., 60 (2), 155–163. URL (abstract): h http://www.ncbi.nlm.nih.gov/pubmed/18444146 (accessed 09.30.2011).

A1–A3, A5, C Schomburg, L., & Köhrle, J. 2008. On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health. Mol. Nutr. Food Res., 52 (11), 1235-1246. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18686295 (accessed 10.04.2011).

A1–A3, A5 Robin, C. 2007. Iodine Remedies: Secrets from the Sea, 36. Madison, WI: Service to the Good of Life. URL (PDF): www.jcrows.com/MaryJoFahey_IodineRemediesSecretsFromTheSea.pdf (accessed 05.18.2009).

B, C Schroeder, J., et al. 2005. Safety and intestinal tolerance of high-dose enteral antioxidants and glutamine peptides after upper gastrointestinal surgery. Eur. J. Clin. Nutr., 59 (2), 307-310. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/15508015 (accessed 05.16.2011).

A1–A3, A5 Derumeaux, H., et al. 2003. Association of selenium with thyroid volume and echostructure in 35- to 60-year-old French adults. Eur. J. Endocrinol., 148 (3), 309-315. URL: http://eje-online.org/content/148/3/309.long (accessed 10.04.02011).

A1–A3, A5, B Zimmermann, M., & Köhrle, J. 2002. The impact of iron and selenium deficiencies on iodine and thyroid metabolism: Biochemistry and relevance to public health. Thyroid, 12 (10), 867-878. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12487769 (accessed 09.29.2011).

A1–A3, A5, B Berger, M., et al. 2001. Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: A placebo-controlled trial. Intensive Care Med., 27 (1), 91–100. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11280679 (accessed 05.13.2009).

A1–A3, A5 Erdogan, M., et al. 2001. Endemic goiter, thiocyanate overload, and selenium status in school-age children. Biol. Trace Elem. Res., 79 (2), 121-130. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11330518 (accessed 09.30.2011).

A1–A3, A5 Giray, B., et al. 2001. Status of selenium and antioxidant enzymes of goitrous children is lower than healthy controls and nongoitrous children with high iodine deficiency. Biol. Trace Elem. Res., 82 (1–3), 35-52. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11697777 (accessed 09.29.2011).

B, C Schrauzer, G. 2001. Nutritional selenium supplements: Product types, quality, and safety. J. Am. Coll. Nutr., 20 (1), 1-4. URL: http://www.jacn.org/content/20/1/1.long (accessed 05.16.2011).

A1–A3, A5, B, C Arthur, J., & Beckette, G. 1999. Trace elements and thyroid function. Br. Med. Bull., 55 (3), 658–668. URL: http://bmb.oxfordjournals.org/cgi/reprint/55/3/658 (accessed 05.13.2009).

B, C Hathcock, J. 1997. Vitamins and minerals: efficacy and safety. Am. J. Clin. Nutr., 66 (2), 427-437. URL: http://www.ajcn.org/content/66/2/427.long (accessed 05.16.2011).

B, C Clark, L., et al. 1996. Effect of selenium supplementation supplementation for cancer prevention in patients with carcinoma of the skin. JAMA, 276, 1957–1968. URL: http://www.selenium.arizona.edu/jama/JAMA%20-%20Article%20oc6377.htm (accessed 09.30.2011).

B Whanger, P., et al. 1996. Metabolism of subtoxic levels of selenium in animals and humans. Ann. Clin. Lab. Sci., 26 (2), 99-113. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/8852418 (accessed 10.04.2011).

A1–A3, A5 Olivieri, O., et al. 1995. Low selenium status in the elderly influences thyroid hormones. Clin. Sci. (Lond.), 89 (6) 637–642. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/8549083 (accessed 09.30.2011).

B Yang, G., & Zhou, R. 1994. Further observations on the human maximum safe dietary selenium intake in a seleniferous area of China. J. Trace Elem. Electrolytes Health Dis., 8 (3-4), 159-165. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/7599506 (accessed 05.16.2011).

B, C Blot, W., et al. 1993. Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J. NatI. Cancer Inst., 85 (18), 1483–1492. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/8360931 (accessed 09.30.2011).

A1–A3, A5 Arthur, J., et al. 1992. The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism. Biol. Trace Elemen. Res., 33, 37–42. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/1379458 (accessed 09.30.2011).

A4, C Rannem, T., et al. 1992. Selenium status in patients with Crohn’s disease. Am. J. Clin. Nutr., 56 (5), 933–937. URL: http://www.ajcn.org/content/56/5/933.long (accessed 09.30.2011).

A4, C Brown, M., et al. 1986. Proximal muscle weakness and selenium deficiency associated with long-term parenteral nutrition. Am. J. Clin. Nutr., 43 (4), 549-554. URL: http://www.ajcn.org/content/43/4/549.long (accessed 10.04.2011).

A1–A3, A5 Sterling, K. 1979. Thyroid hormone action at the cell level. NEJM, 300 (3 &4), 117–123; 173–177. Pts 1 & 2. URL’s (extracts): http://www.nejm.org/doi/full/10.1056/NEJM197901183000304 & http://www.nejm.org/doi/full/10.1056/NEJM197901253000405 (accessed 09.30.2011).

How do I use T-Balance Plus?

We recommend starting with two capsules per day — one with breakfast and one with dinner.

How long until I see results?

81% of women who track their progress while using T-Balance Plus along with our recommended guidelines report a significant reduction in their symptoms — with most reporting they feel better in about a month.

Get optimum results with regular use

Science suggests combination herbal formulas, like T-Balance Plus, are highly effective because they work in an adaptogenic way to address the root of the symptoms. Herbs work at the source of the imbalance, “upstream” of where most drugs take aim. With just a little time and the right combination of herbs, a woman’s body can repair hormonal pathways that have been off-balance for many years.

We formulate our supplements so the nutrients are highly bioavailable. There are no toxins, hormone disruptors, artificial preservatives, or synthetic dyes. Our philosophy is to provide the right support for your body so it can balance its hormones naturally, as it was meant to do.

How long will a bottle last?

One bottle of T-Balance Plus is designed to last 30 days.

Average Ratings

94% recommend T-Balance

Overall Rating:
Quality:
Satisfaction:
Customer Service:

Showing 1-10 of 126 reviews

Review by Margi on 06/06/2017

Would Recommend: Yes
Overall Rating:
Quality:
Satisfaction:
Customer Service:
My thyroid was borderline low. I prefer to use natural products if possible. This brought stabilized my thyroid. The emails are helpful and informative.

Review by Mary on 05/26/2017

Would Recommend: Yes
Overall Rating:
Quality:
Satisfaction:
Customer Service:
I've been taking T balance and I love it I feel great and have lots of energy. I prefer to take T balance than the doctor's medication..

Review by Joanna on 04/24/2017

Would Recommend: Yes
Overall Rating:
Quality:
Satisfaction:
Customer Service:
I have taken one bottle, and I feel much better. I have a little more energy, and my mind is clearer. I have been sleeping great too. I have not noticed any weight loss yet, but hopefully I will soon. I highly recommend this product for women with fatigue, weight gain and sluggish or fuzzy brain function.

Review by Tiny on 04/09/2017

Would Recommend: Yes
Overall Rating:
Quality:
Satisfaction:
Customer Service:

Review by Brittany on 03/31/2017

Would Recommend: Yes
Overall Rating:
Quality:
Satisfaction:
Customer Service:
I have been taking this product for 3 weeks and have noticed a significant decrease in my hair loss due to my thyroid. I am def. reordering this product for continued use and am confident that it will help with my other symptoms.

Review by Lynn on 03/28/2017

Would Recommend: Yes
Overall Rating:
Quality:
Satisfaction:
Customer Service:

Review by Georgia on 03/26/2017

Would Recommend: Yes
Overall Rating:
Quality:
Satisfaction:
Customer Service:
I have been battling fatigue for a couple years. Went thru all the Doctor tests only to be told everything is normal. Finally this winter I got tired of the constant sore throat and body aches. I decided to go and try their quizzes and products. Well I'm feeling better and am finally energized enough to start to enjoy my horses again. I sleep better and don't have the body aches with the sore throat. It is so nice. Just started my 2nd month.

Review by eeh on 03/25/2017

Would Recommend: Yes
Overall Rating:
Quality:
Satisfaction:
Customer Service:
I did not notice any difference with this supplement. I tried it for two months.

Review by Amarie on 02/28/2017

Would Recommend: Yes
Overall Rating:
Quality:
Satisfaction:
Customer Service:

Review by Bitsy on 01/19/2017

Would Recommend: Yes
Overall Rating:
Quality:
Satisfaction:
Customer Service:
I haven't had my blood work done yet to see how I'm doing off of my synthroid, I'm feeling good, no dizziness like before when I tried to go off of the synthroid so I'm optimistic. Customer service is great!!


Just $29.95

Add to Cart
T-Balance

T-Balance Plus

T-Balance Plus

Get fast, natural relief from the symptoms of underactive or low thyroid:

Average product rating: 
| 94% recommend T-Balance

  • Relieves symptoms – including fatigue, lack of energy, weight gain, fuzzy thinking, hair loss and sensitivity to cold
  • Restores thyroid balance and supports healthy thyroid function
  • Contributes to stable moods and mitigates mild depression
  • Helps holistically harmonize the thyroid with the body’s overall endocrine system
  • Ensures adequate iodine, a nutrient that when deficient can trigger thyroid problems

Join the 81% of women who report significant symptom relief with our alternative approach, most in less than 30 days. Our exclusive herbal formula is safe, bioavailable, manufactured to the FDA’s highest standards, and importantly, based on the latest science. Try T-Balance Plus today and say goodbye to your symptoms forever!

Our guarantee