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Melatonin

Melatonin

Melatonin is so important to sleep that your body makes it naturally as a hormone that helps maintain a healthy circadian rhythm. Like many other hormones, melatonin levels rise and fall naturally during every 24-hour period. For the best sleep, melatonin should increase during the evening hours, stay high throughout the night and drop as morning approaches. Supplementing with Melatonin can help you feel sleepier and reduce the time it takes to fall asleep. Research shows it may also help you sleep longer.

How will Melatonin help you?

  • Acts on the brain receptors that regulate the body’s circadian clock.
  • Improves ability to fall asleep at bedtime.
  • Supports healthy sleep cycles.
  • Helps counter wakefulness.
  • Often used to help relieve occasional insomnia.
  • Helps with fatigue from jet lag and shift-work sleep disruptions.

Our Melatonin is:

  • Made without preservatives, sugar, artificial flavoring, dyes or coloring of any kind.
  • Manufactured in a facility validated by NSF International to meet or exceed all government regulations for Good Manufacturing Processes (the FDA's GMP's).
  • Laboratory-assayed to ensure quality.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Melatonin Ingredients

Product References

Women’s Health Network Melatonin is doctor-formulated to be complete, natural, bioavailable and manufactured to pharmaceutical standards.

The following articles and studies, arranged alphabetically, represent a sampling of the research on the melatonin.

Alvarez B., et al. 1992. The delayed sleep phase syndrome: Clinical and investigative findings in 14 patients. J Neurol Neurosurg Psychiatry.55:665-670. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/1527536 (accessed 07/10/2013).

Appleton, R. E., & Gringras, P. 2013. Melatonin: helping to MEND impaired sleep. Arch Dis Child. 98:216-217. URL (abstract only): http://adc.bmj.com/content/98/3/216.extract (accessed 07/10/2013).

Armstrong, S.M. & Redman, J.R. 1991. Melatonin: A chronobiotic with anti-aging properties? Med Hypotheses. 34:300-309. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/1865836 (accessed 07/10/2013).

Beck-Friis J., et al. 1985. Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome. Acta Psychiatr Scand.71:319-330. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/4039876 (accessed 07/10/2013).

Bismar, K., et al. 1987. Depressed melatonin secretion in patients with nightmares due to beta adrenoceptor blocking drug. Acta Med Scand. 221:155-158. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/2884812 (accessed 07/10/2013).

Brown, G.M., et al. 2009. Melatonin and its relevance to jet lag. Travel Med Infect is. 7(2): 69-81. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/19237140 (accessed 07/10/2013).

Cardinali, D.P., et al. 2011. The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer’s disease. Recent Pat Endocr Metab Immune Drug Discov. 5(2): 80-90. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/22074583 (accessed 07/10/2013).

Carpentieri, A., et al. 2012. New perspectives in melatonin uses. Pharmacol Res. 65(4): 437-44. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/22311380 (accessed 07/10/2013).

Comperatore, C. A., et al. 1996. Melatonin efficacy in aviation missions requiring repaid deployment and night operations. Aviat Space Environ Med. 67(6):520-4. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/8827132 (accessed 07/10/2013).

Dahlitz, M., et al. 1991. Delayed sleep phase syndrome response to melatonin. Lancet. 337:1121-1124. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/1674014 (accessed 07/10/2013).

Dawson, D. & Armstrong, S.M. 1996. Chronobiotics – drugs that shift rhythms. Pharmacol Ther. 69 (1): 15-36. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/8857301 (accessed 07/10/2013).

Dijk, D. J., et al. 2012. Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans. PLoS One. 7(2):e30037. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/22363414 (accessed 07/10/2013).

Eckerberg, B., et al. 2012. Melatonin treatment effects on adolescent students’ sleep timing and sleepiness in a placebo-controlled crossover study. Chronobiol Int. 29(9): 1239-48. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/23005039 (accessed 07/10/2013).

Elbaz, I., et al. 2013. Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish. Front Neural Circuits. Epub February 1, 2013. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561628/ (accessed 06/13/2013).

Gorfine, T., et al. 2006. S;eep-anticipating effects of melatonin in the human brain. Neuroimage. 31(1): 410-8. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/16427787 (accessed 07/10/2013).

Jan, J.E. & Freeman, R.D. 2007. Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade? Developmental Medicine & Child Neurology. 46(11): 776-782. URL (abstract only): http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.2004.tb00999.x/abstract (accessed 07/10/2013).

Jarratt, J. 2011. Perioperative melatonin use. Anaesth Intensive Care. 39(2): 171-81. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/21485664 (accessed 07/10/2013).

Lieberman, H.R. 1989. Behavior, sleep and melatonin. J Neural Transm Suppl. 21:233-241. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/3462333 (accessed 07/10/2013).

Lieberman, H.R., et al. 1985. Possible behavioral consequences of light-induced changes in melatonin availability. Ann N Y Acad Sci. 453: 242-52. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/3865584 (accessed 07/10/2013).

Lieberman, H.R., et al. 1984. Effects of melatonin on human mood and performance. Brain Res. 323(2): 201-7. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/6525511 (accessed 07/10/2013).

Lissoni, P., et al. 1992. Randomized study with the pineal hormone melatonin versus supportive care alone in advanced nonsmall cell lung cancer resistant to a first-line chemotherapy containing cisplatin. Oncology. 49(5): 336-9. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/1382256 (accessed 07/10/2013).

Lissoni, P., et al. 1991. Clinical results with the pineal hormone melatonin in advanced cancer resistant to standard antitumor therapies. Oncology. 48:448-450. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/1749579 (accessed 07/10/2013).

Lissoni, P., et al. 1989. Endocrine and immune effects of melatonin therapy in metastatic cancer patients. Eur J Cancer Clin Oncol. 25(5): 789-95. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/2525469 (accessed 07/10/2013).

Lyseng-Williamson, K.A. 2012. Melatonin prolonged release: in the treatment of insomnia in patients aged =55 years. Drugs Aging. 29(11): 911-23. ULR (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/23044640 (accessed 07/10/2013).

Paul, M.A., et al. 2011. Phase advance with separate and combined melatonin and light treatment. Psychopharmacology (Berl.). 214(2): 515-23. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/21069516 (accessed 07/10/2013).

Paul, M.A., et al. 2010. Melatonin treatment for eastward and westward travel preparation. Psychopharacology (Berl). 208(3): 377-86. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/20013115 (accessed 07/10/2013).

Petterborg, L. J., et al. 1991. Effect of melatonin replacement on serum hormone rhythms in a patient lacking endogenous melatonin. Brain Res Bull. 27(2): 181-5. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/1742605 (accessed 07/10/2013).

Radeljak, S., et al. 2008. Chromotherapy in the regulation of neurohormonal balance in human brain – complementary application in modern psychiatric treatment. Coll Antropol. 32 Suppl 2: 185-8. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/19138024 (accessed 07/10/2013).

Reiter, R.J. & Korkmaz, A. 2008. Clinical aspects of melatonin. Saudi Med J.29(11): 1537-47. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/18997997 (accessed 07/10/2013).

Rios, E.R., et al. 2012. Melatonin: pharmacological aspects and clinical trends. Int J Neurosci. 120(9): 583-90. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/20707632 (accessed 07/10/2013).

Scheer, F.A., et al. 2012. Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. Sleep. 35(10): 1395-402. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/23024438 (accessed 07/10/2013).

Srinivasan, V., et al. 2009. Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int J Neurosci. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/19326288 (accessed 07/10/2013).

Turek, F.W. & Gillette, M.U. 2004. Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Sleep Med. 5(6): 523-32. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/15511698 (accessed 07/10/2013).

Waldhauser, F., et al. 1987. A pharmacological dose of melatonin increases PRL levels in males without altering those of GH, LH, FSH, TSH, testosterone or cortisol. Neuroendocrinology. 46(2): 125-30. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/3114663 (accessed 07/10/2013).

Waldhauser, F., et al. 1984. Bioavailability of oral melatonin in humans. Neuroendocrinology. 39(4): 307-13. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/6493445 (accessed 07/10/2013).

Wyatt, J.K., et al. 2006. Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent. Sleep. 29(5): 609-18. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/16774150 (accessed 07/10/2013).

Zawilska, J.B., et al. 2009. Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacol Rep. 61(3): 383-410. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/19605939 (accessed 07/10/2013).

Average Ratings

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Review by Priscilla on 05/02/2016

Would Recommend: Yes
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I have tried quite a few things for sleeping and nothing has worked as well. I've taken other melatonin that wasn't helpful.

Review by Tina on 02/10/2015

Would Recommend: Yes
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Review by Marilyn on 06/26/2014

Would Recommend: Yes
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Has really helped me sleep. You need melatonin as you age because your body does not make as much.

Review by Marilyn on 05/09/2014

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Women's Health Network is awesome and so are the products. They really care and they listen when you call.

Review by Bearmsw on 04/22/2014

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