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RED Revitalizer

RED Revitalizer

Find the health and wellness you deserve with our exclusive RED Revitalizer, our comprehensive lifestyle supplement. Developed by Dr. Sharon Stills, NMD, and Women’s Health Network, this natural supplement is packed with powerful, plant-based ingredients, key minerals and antioxidant vitamins. The RED Revitalizer is formulated specifically for women who want to feel energetic and alert every day. It provides support for immunity, healthy skin, liver detoxification, blood sugar balance and cognitive performance. It also helps fight free radicals and the effects and symptoms of stress.

How else will the ingredients in Revitalizer help you?

  • Support healthy skin and healthy aging
  • Help maintain healthy skin and collagen
  • Help improve mood
  • Counter oxidative stress to help protect cells
  • Support hormone balance
  • Support the ability to focus and have a beneficial effect on brain health

The RED Revitalizer is:

  • Formulated to support immunity, cognitive function, hormonal balance, healthy blood sugar and liver detoxification.
  • Made from the highest quality ingredients and free of artificial preservatives, colors, sweeteners or flavors.
  • Manufactured in a facility validated by NSF International to meet or exceed all governmental requirements for Good Manufacturing Practices (the FDA's GMP's).

About RED

RED is about coming into your own and celebrating your life, perhaps for the first time ever. Created by Dr. Sharon Stills, NMD, RED is a philosophy, a way of life and a path to realize your dreams and desires. Many women start their RED life by reinventing their health, one step at a time.

Dr. Sharon Stills, NMD

About Dr. Stills

Dr. Sharon Stills, NMD, is an innovative natural health practitioner who provides therapeutic and diagnostic services to women. She is a member of the American Association of Naturopathic Physicians, the Arizona Naturopathic Medical Association and the Oncology Association of Naturopathic Physicians. Dr. Stills authors and reviews articles and is a member of the Women’s Health Network Expert Panel.

How to use:

We recommend taking four tablets per day — two with breakfast and two with lunch. For best results, don’t take this formula near bedtime. Use this formula as directed for at least 30-60 days.

The RED Revitalizer is intended to last a full 30 days.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
RED Revitalizer Ingredients

Product References

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Pantothenic Acid

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Beet

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Pomegranate

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Cranberry
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Red Raspberry Leaf
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Olive Leaf

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Lockyer S, Corona G, Yaqoob P, Spencer JP, Rowland I. Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: a randomised, double­ blind, placebo­controlled, cross­over trial. Br J Nutr. 2015 Jul 14;114(1):75­83. doi: 10.1017/S0007114515001269. Epub 2015 Jun 8. PubMed PMID: 26051429.
Efentakis P, Iliodromitis EK, Mikros E, Papachristodoulou A, Dagres N, Skaltsounis AL, Andreadou I. Effects of the olive tree leaf constituents on myocardial oxidative damage and atherosclerosis. Planta Med. 2015 Jun;81(8):648­54. doi: 10.1055/s­0035­1546017. Epub 2015 May 27. Review. PubMed PMID: 26018920.

Vogel P, Kasper Machado I, Garavaglia J, Zani VT, de Souza D, Morelo Dal Bosco S. Polyphenols benefits of olive leaf (Olea europaea L) to human health. Nutr Hosp. 2014 Dec 17;31(3):1427­33. doi: 10.3305/nh.2015.31.3.8400. Review. PubMed PMID: 25726243.
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Dell'Agli M, Di Lorenzo C, Badea M, Sangiovanni E, Dima L, Bosisio E, Restani P. Plant food supplements with anti­inflammatory properties: a systematic review (I). Crit Rev Food Sci Nutr. 2013;53(4):403­13. doi: 10.1080/10408398.2012.682123. Review. PubMed PMID: 23320910.

de Bock M, Derraik JG, Brennan CM, Biggs JB, Morgan PE, Hodgkinson SC, Hofman PL, Cutfield WS. Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle­aged overweight men: a randomized, placebo­controlled, crossover trial. PLoS One. 2013;8(3):e57622. doi: 10.1371/journal.pone.0057622. Epub 2013 Mar 13. PubMed PMID: 23516412; PubMed Central PMCID: PMC3596374.

Wainstein J, Ganz T, Boaz M, Bar Dayan Y, Dolev E, Kerem Z, Madar Z. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Med Food. 2012 Jul;15(7):605­10. doi: 10.1089/jmf.2011.0243. Epub 2012 Apr 18. PubMed PMID: 22512698.

Taamalli A, Arráez­Román D, Zarrouk M, Valverde J, Segura­Carretero A, Fernández­Gutiérrez A. The occurrence and bioactivity of polyphenols in Tunisian olive products and by­products: a review. J Food Sci. 2012 Apr;77(4):R83­92. doi: 10.1111/j.1750­3841.2011.02599.x. Epub 2012 Feb 21. Review. PubMed PMID: 22352878.
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Green Tea

Brown, A., et al. 2011. Health effects of green tea catechins in overweight and obese men: A randomised controlled cross-over trial. Br. J. Nutr. [Epub ahead of print.]
Jeukendrup, A., & Randell, R. 2011. Fat burners: Nutrition supplements that increase fat metabolism. Obes. Rev., 12 (10), 841-851.
Sae-tan, S., et al. 2011. Weight control and prevention of metabolic syndrome by green tea. Pharmacol. Res., 64 (2), 146-154.
Reinbach, H., et al. 2009. Effects of capsaicin, green tea and CH-19 sweet pepper on appetite and energy intake in humans in negative and positive energy balance. Clin. Nutr., 28 (3), 260-265.
Bose, M., et al. 2008. The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice. J. Nutr., 138 (9), 1677-
Boschmann M and Thielecke F. 2007. The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study. J Am Coll Nutr. 26(4):389S-395S.
Belza A, Jessen AB. 2005. Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation. Eur J Clin Nutr. 9(6):733-41.
Kovacs, E., et al. 2004. Effects of green tea on weight maintenance after body-weight loss. Br. J. Nutr. 91, 431–437.
Nagao, T., et al. 2005. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr. 81:122–9.
Rumpler W., et al. 2001. Oolong tea increases metabolic rate and fat oxidation in men. J Nutr. 2001;131:2848–52.
Dulloo AG et al. 1999. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 70(6):1040-5.
Dulloo AG et al. 2000. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord. 24(2):252-8.

Alpha-Lipoic acid

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Jacob S, Henriksen EJ, Schiemann AL, Simon I, Clancy DE, Tritschler HJ, Jung WI, Augustin HJ, Dietze GJ, 1995. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung, 45, 872-874.
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Kamenova P, 2006. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens), 5, 251-258.
Konrad T, Vicini P, Kusterer K, Hoflich A, Assadkhani A, Bohles HJ, Sewell A, Tritschler HJ, Cobelli C, Usadel KH, 1999. alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care, 22, 280-287.
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Piehl Aulin K, Soderlund K, Hultman E, 2000. Muscle glycogen resynthesis rate in humans after supplementation of drinks containing carbohydrates with low and high molecular masses. Eur J Appl Physiol, 81, 346-351.
Reljanovic M, Reichel G, Rett K, Lobisch M, Schuette K, Moller W, Tritschler HJ, Mehnert H, 1999. Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. Free Radic Res, 31, 171-179.
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Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM, 2004. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem, 11, 1135-1146.
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Stevens MJ, Obrosova I, Cao X, Van Huysen C, Greene DA, 2000. Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy. Diabetes, 49, 1006-1015.
Stitt A, Gardiner TA, Alderson NL, Canning P, Frizzell N, Duffy N, Boyle C, Januszewski AS, Chachich M, Baynes JW, Thorpe SR, 2002. The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes. Diabetes, 51, 2826-2832.
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Teichert J, Tuemmers T, Achenbach H, Preiss C, Hermann R, Ruus P, Preiss R, 2005. Pharmacokinetics of alpha-lipoic acid in subjects with severe kidney damage and end-stage renal disease. J Clin Pharmacol, 45, 313-328.
Ternes W, Täufel A, Tunger L, Zobel M, 2005. Lebensmittel-Lexikon. Behr's Verlag, Hamburg.
Thirunavukkarasu V, Anitha Nandhini AT, Anuradha CV, 2005. Lipoic acid improves glucose utilisation and prevents protein glycation and AGE formation. Pharmazie, 60, 772-775.
Voloboueva LA, Liu J, Suh JH, Ames BN, Miller SS, 2005. (R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci, 46, 4302-4310.
Wollin SD and Jones PJ, 2003. Alpha-lipoic acid and cardiovascular disease. J Nutr, 133, 3327-3330.
Yi X and Maeda N, 2006. alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes, 55, 2238-2244.
Ziegler D, Hanefeld M, Ruhnau KJ, Hasche H, Lobisch M, Schutte K, Kerum G, Malessa R, 1999. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy. Diabetes Care, 22, 1296-1301.

Ashwagandha

Alam, N., et al. 2011. High catechin concentrations detected in Withania somnifera (ashwagandha) by high performance liquid chromatography analysis. BMC Complement. Altern. Med., 11, 65. URL: http://www.biomedcentral.com/1472-6882/11/65
Sinha, S., et al. 2011. In vivo anti-tussive activity and structural features of a polysaccharide fraction from water extracted Withania somnifera. J Ethnopharmacol. 2011 Mar 24;134 (2), 510-513.
Dog, T. 2010. Smart Talk on supplements and botanicals: Ginseng and other adaptogenic herbs. Alt. Complement. Ther., 16 (1), 1–4. URL (paid access): http://www.liebertonline.com/doi/abs/10.1089/act.2010.16101 (accessed 01.17.2011).
Ven Murthy, M., et al. 2010. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: Ashwagandha. Cent. Nerv. Syst. Agents Med. Chem., 10 (3), 238-246.
Yadav, B., et al. 2010. In vitro anticancer activity of the root, stem and leaves of Withania somnifera against various human cancer cell lines. Indian J. Pharm. Sci., 72 (5), 659-663. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116319/?tool=pubmed (accessed 09.23.2011).
Widido, N., et al. 2007. Selective killing of cancer cells by leaf extract of Ashwagandha: Identification of a tumor-inhibitory factor and the first molecular insights to its effect. Clin. Cancer Res., 13 (7), 2298–2306.
Naidu, P., et al. 2006. Effect of Withania somnifera root extract on reserpine-induced orofacial dyskinesia and cognitive dysfunction. Phytother. Res., 20 (2), 140–146.
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Kuboyama, T., et al. 2005. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br. J. Pharmacol., 144 (7), 961–971.
Misra, L., et al. 2005. Unusually sulfated and oxygenated steroids from Withania somnifera. Phytochemistry, 66, 2702–2707.
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Sreerekha, M., et al. 2004. Distribution of total withanolides in various plant parts of Ashwagandha (Withania somnifera) accessions as influenced by light and dark reaction cycle. J. Med. Aromatic Plant Sci., 26, 681–683. URL
Bhattacharya, S., & Muruganandam, A. 2003. Adaptogenic activity of Withania somnifera: An experimental study using a rat model of chronic stress. Pharmacol. Biochem. Behav., 75, 547–555.
Iuvone, T., et al. 2003. Induction of nitric oxide synthase expression by Withania somnifera macrophages. Life Sci., 72 (14), 1617-1625.
Ilayperuma, I., et al. 2002. Effect of Withania somnifera root extract on the sexual behaviour of male rats. Asian J. Androl., 4, 295–298.
Rajpal, V. 2002. Standardization of botanicals. New Delhi: Eastern Publishers.
Abdel–Magied, E., et al. 2001. The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats. J. Ethnopharmacol., 75 (1), 1–4.
Dhuley, J. 2001. Nootropic-like effect of Ashwagandha (Withania somnifera L.) in mice. Phytother Res., 15 (6), 524–528.
Jain, S., et al. 2001. Neuroprotective effects of Withania somnifera Dunn. in hippocampal sub-regions of female albino rat. Phytother. Res., 15 (6), 544–548.
Singh, B., et al. 2001. Adaptogenic activity of a glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaertn. Phytomedicine, 8, 283–291.
Singh, G., et al. 2001. Adaptogenic activity of a novel, withanolide-free aqueous fraction from the roots of Withania somnifera Dunn. Phytother. Res., 15 (4), 311–318.
Battacharya, S., et al. 2000. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: An experimental study. Phytomedicine, 7 (6), 463–469.
Dhuley, J. 2000. Adaptogenic and cardioprotective action of ashwagandha in rats and frogs. J. Ethnopharmacol., 70 (1), 57–63.
Mishra, L-C., et al. 2000. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): A review. Altern. Med. Rev., 5 (4), 334–346.
Archana, R., & Namasivayam, A. 1999. Antistressor effect of Withania somnifera. J. Ethnopharmcol., 64 (1), 91–93.
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al-Hindawi, M., et al. 1992. Anti-granuloma activity of Iraqi Withania somnifera. J. Ethnopharmacol., 37 (2), 113–116.
Mehta, A., et al. 1991. Pharmacologic effects of Withania somnifera root extract on GABAA receptor complex. Indian J. Med. Res., 94, 312–315.
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Dandelion

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González-Castejón M, Visioli F, Rodriguez-Casado A. Diverse biological activities of dandelion. Nutr Rev. 2012 Sep;70(9):534-47. doi: 10.1111/j.1753-4887.2012.00509.x. Epub 2012 Aug 17. Review. PubMed PMID: 22946853.
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Martinez M, Poirrier P, Chamy R, Prüfer D, Schulze-Gronover C, Jorquera L, Ruiz G. Taraxacum officinale and related species-An ethnopharmacological review and its potential as a commercial medicinal plant. J Ethnopharmacol. 2015 Jul 1;169:244-62. doi: 10.1016/j.jep.2015.03.067. Epub 2015 Apr 6. Review. PubMed PMID: 25858507.
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Rodriguez-Casado A. The Health Potential of Fruits and Vegetables Phytochemicals: Notable Examples. Crit Rev Food Sci Nutr. 2016 May 18;56(7):1097-107. doi: 10.1080/10408398.2012.755149. Review. PubMed PMID: 25225771.
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Valussi M. Functional foods with digestion-enhancing properties. Int J Food Sci Nutr. 2012 Mar;63 Suppl 1:82-9. doi: 10.3109/09637486.2011.627841. Epub 2011 Oct 19. Review. PubMed PMID: 22010973.

Holy basil

Baliga MS, Rao S, Rai MP, D'souza P. Radio protective effects of the Ayurvedic medicinal plant Ocimum sanctum Linn. (Holy Basil): A memoir. J Cancer Res Ther. 2016 Jan-Mar;12(1):20-7. doi: 10.4103/0973-1482.151422. Review. PubMed PMID: 27072205.
Sampath S, Mahapatra SC, Padhi MM, Sharma R, Talwar A. Holy basil (Ocimum sanctum Linn.) leaf extract enhances specific cognitive parameters in healthy adult volunteers: A placebo controlled study. Indian J Physiol Pharmacol. 2015 Jan-Mar;59(1):69-77. PubMed PMID: 26571987.
Cohen MM. Tulsi - Ocimum sanctum: A herb for all reasons. J Ayurveda Integr Med. 2014 Oct-Dec;5(4):251-9. doi: 10.4103/0975-9476.146554. Review. PubMed PMID: 25624701; PubMed Central PMCID: PMC4296439.
Kamyab AA, Eshraghian A. Anti-Inflammatory, gastrointestinal and hepatoprotective effects of Ocimum sanctum Linn: an ancient remedy with new application. Inflamm Allergy Drug Targets. 2013 Dec;12(6):378-84. Review. PubMed PMID: 24266685.
Bhattacharyya P, Bishayee A. Ocimum sanctum Linn. (Tulsi): an ethnomedicinal plant for the prevention and treatment of cancer. Anticancer Drugs. 2013 Aug;24(7):659-66. doi: 10.1097/CAD.0b013e328361aca1. Review. PubMed PMID: 23629478.
Baliga MS, Jimmy R, Thilakchand KR, Sunitha V, Bhat NR, Saldanha E, Rao S, Rao P, Arora R, Palatty PL. Ocimum sanctum L (Holy Basil or Tulsi) and its phytochemicals in the prevention and treatment of cancer. Nutr Cancer. 2013;65 Suppl 1:26-35. doi: 10.1080/01635581.2013.785010. Review. PubMed PMID: 23682780.
Mondal S, Varma S, Bamola VD, Naik SN, Mirdha BR, Padhi MM, Mehta N, Mahapatra SC. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J Ethnopharmacol. 2011 Jul 14;136(3):452-6. doi: 10.1016/j.jep.2011.05.012. Epub 2011 May 17. PubMed PMID: 21619917.
Bhat J, Damle A, Vaishnav PP, Albers R, Joshi M, Banerjee G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. Phytother Res. 2010 Jan;24(1):129-35. doi: 10.1002/ptr.2889. PubMed PMID: 19504465.
Mondal S, Mirdha BR, Mahapatra SC. The science behind sacredness of Tulsi (Ocimum sanctum Linn.). Indian J Physiol Pharmacol. 2009 Oct-Dec;53(4):291-306. Review. PubMed PMID: 20509321.
Bhattacharyya D, Sur TK, Jana U, Debnath PK. Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Med Coll J. 2008 Sep;10(3):176-9. PubMed PMID: 19253862.
Singh S, Taneja M, Majumdar DK. Biological activities of Ocimum sanctum L. fixed oil--an overview. Indian J Exp Biol. 2007 May;45(5):403-12. Review. PubMed PMID: 17569280.
Prakash P, Gupta N. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian J Physiol Pharmacol. 2005 Apr;49(2):125-31. Review. PubMed PMID: 16170979.
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Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002 Jun;81(1):81-100. Review. PubMed PMID: 12020931.
Uma Devi P. Radioprotective, anticarcinogenic and antioxidant properties of the Indian holy basil, Ocimum sanctum (Tulasi). Indian J Exp Biol. 2001 Mar;39(3):185-90. Review. PubMed PMID: 11495275.
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Agrawal P, Rai V, Singh RB. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther. 1996 Sep;34(9):406-9. PubMed PMID: 8880292.

Milk Thistle

Allain, H, Schuck, S, Lebreton, S, Strenge-Hesse, A, Braun, W, Gandon, JM, Brissot, P. Aminotransferase levels and silymarin in de novo tacrine-treated patients with Alzheimer's disease. Dement Geriatr Cogn Disord 1999;10:181-5.
Bass, NM. Is there any use for nontraditional or alternative therapies in patients with chronic liver disease? [In Process Citation]. Curr Gastroenterol Rep 1999;1:50-6.
Berkson, BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Med Klin 1999;94 Suppl 3:84-9.
Edwards, J, Grange, LL, Wang, M, Reyes, E. Fetoprotectivity of the flavanolignan compound siliphos against ethanol- inducedtoxicity [In Process Citation]. Phytother Res 2000;14:517-21.
Farghali, H, Kamenikova, L, Hynie, S, Kmonickova, E. Silymarin effects on intracellular calcuim and cytotoxicity: a study in perfused rat hepatocytes after oxidative stress injury. Pharmacol Res 2000;41:231-7.
Flora, K, Hahn, M, Rosen, H, Benner, K. Milk thistle (Silybum marianum) for the therapy of liver disease [see comments]. Am J Gastroenterol 1998;93:139-43.
Kropacova, K, Misurova, E, Hakova, H. Protective and therapeutic effect of silymarin on the development of latent liver damage. Radiats Biol Radioecol 1998;38:411-5.
Par, A, Roth, E, Rumi, G, Jr., Kovacs, Z, Nemes, J, Mozsik, G. [Oxidative stress and antioxidant defense in alcoholic liver disease and chronic hepatitis C]. Orv Hetil 2000;141:1655-9.
Zhao, J, Sharma, Y, Agarwal, R. Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion. Mol Carcinog 1999;26:321-33.
Zhao, J, Agarwal, R. Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Carcinogenesis 1999;20:2101-8.

Rhodiola

Hung, S., et al. 2011. The effectiveness and efficacy of Rhodiola rosea L.: A systematic review of randomized clinical trials. Phytomedicine, 18 (4), 235–244. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21036578 (accessed 02.21.2011).
Calcabrini, C., et al. 2010. Rhodiola rosea ability to enrich cellular antioxidant defenses of cultured human keratinocytes. Arch. Dermatol. Res., 302 (3), 191–200.
Cifani, C., et al. 2010. Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating. Physiol. Behav., 101 (5), 555–562.
Panossian, A., et al. 2010. Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine, 17 (7), 481–493.
Parisi, A., et al. 2010. Effects of chronic Rhodiola rosea supplementation on sport performance and antioxidant capacity in trained male: Preliminary results. J. Sports Med. Phys. Fitness, 50 (1), 57–63.
Evdokimov,V. 2009. [Effect of cryopowder Rhodiola rosae L. on cardiorespiratory parameters and physical performance of humans]. Aviakosm. Ekolog. Med., 43 (6), 52–56.
Huang, S., et al. 2009. Attenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the rat. Chin. J. Physiol., 52 (5), 316–324.
Jeong, H., et al. 2009. Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg. Med. Chem., 17 (19), 6816–6823.
Lee, F., et al. 2009. Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance. Am. J. Chin. Med., 37 (3), 557–572.
Mattioli, L., et al. 2009. Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats. J. Psychopharmacol., 23 (2), 130–142.
Olsson, E., et al. 2009. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med., 75 (2)
Panossian, A., et al. 2009. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. Phytomedicine. [Epub ahead of print.]
Pooja, et al. 2009. Anti-inflammatory activity of Rhodiola rosea —“a second-generation adaptogen.” Phytother. Res., 23 (8), 1099–1102.
Qu, Z., et al. 2009. Pretreatment with Rhodiola rosea extract reduces cognitive impairment induced by intracerebroventricular streptozotocin in rats: Implication of anti-oxidative and neuroprotective effects. Biomed. Environ. Sci., 22 (4), 318–326.
Schutgens, F., et al. 2009. The influence of adaptogens on ultraweak biophoton emission: A pilot experiment. Phytother. Res.
Skarpanska–Stejnborn, A., et al. 2009. The influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowers. Int. J. Sport Nutr. Exerc. Metab., 19 (2), 186–199.
van Dierman, D., et al. 2009. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J. Ethnopharmacol., 122 (2), 397–401.
Wang, H., et al. 2009. The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3. Phytomedicine, 16 (2-3), 146–155.
Bocharov, E., et al. 2008. [Neuroprotective features of phytoadaptogens.] Vestn. Ross. Akad. Med. Nauk. (4), 47–50.
Bystritsky, A., et al. 2008. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J. Altern. Complement. Med., 14 (2), 175-180.
Chen, Q., et al. 2008. [Effects of Rhodiola rosea on body weight and intake of sucrose and water in depressive rats induced by chronic mild stress.] Zhong Xi Yi Jie He Xue Bao, 6 (9), 952–959.
Chen, T., et al. 2008. Antioxidant evaluation of three adaptogenic extracts. Am. J. Chin. Med., 36 (6), 1209–1217.
Kobayashi, K., et al. 2008. Constituents of Rhodiola rosea showing inhibitory effect on lipase activity in mouse plasma and alimentary canal. Planta Med., 74 (14), 1716-1719.
Panossian, A., et al. 2008. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine, 15 (1–2), 84-91.
Qin, Y., et al. 2008. [Effects of Rhodiola rosea on level of 5-hydroxytryptamine, cell proliferation and differentiation, and number of neurons in cerebral hippocampus of rats with depression induced by chronic mild stress.] Zhongguo Zhong Yao Za Zhi, 33 (23), 2842–2846.
Shen, W., et al. 2008. [Effects of Rhodiola on expression of vascular endothelial cell growth factor and angiogenesis in aortic atherosclerotic plaque of rabbits.] Zhongguo Zhong Xi Yi Jie He Za Zhi, 28 (11), 1022–1025.
Darbinyan, V., et al. 2007. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord. J. Psychiatry, 61 (5), 343-348. Erratum in: Nord. J. Psychiatry, 2007; 61 (6):503.
Fintelmann, V., & Gruenwald, J. 2007. Efficacy and tolerability of a Rhodiola rosea extract in adults with physical and cognitive deficiencies. Adv. Ther., 24 (4), 929-939.
Mattioli, L., & Perfumi, M. 2007. Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats. J. Psychopharmacol., 21 (7), 742-750.
Jafari, M., et al. 2007. Rhodiola: A promising anti-aging Chinese herb. Rejuvenation Res., 10 (4), 587-602.
Perfumi, M., & Mattioli, L. 2007. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother. Res., 21 (1), 37-43.
Walker, T., et al. 2007. Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained men. Metabolism, 56 (8), 1111–1117.
Kim, S., et al. 2006. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors, 26 (3), 209–219.
Kwon Y., et al. 2006. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac. J. Clin. Nutr., 15 (3), 425-432.
Ming, D., et al. 2005. Bioactive compounds from Rhodiola rosea (Crassulaceae). Phytother. Res., 19 (9), 740–743.
Narimanian, M., et al. 2005. Impact of Chisan (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia. Phytomedicine, 12 (10), 723–729.
De Bock, K., et al. 2004. Acute Rhodiola rosea intake can improve endurance exercise performance. Int. J. Sport Nutr. Exerc. Metab., 14 (3), 298–307.
Earnest, C., et al. 2004. Effects of a commercial herbal-based formula on exercise performance in cyclists. Med. Sci. Sports Exerc., 36 (3), 504-509.
Hudson, T. 2004. Women’s health update: Rhodiola rosea. Townsend Lett.
Kucinskaite, A., et al. 2004. [Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine.] Medicina (Kaunas), 40 (7), 614–619.
Abidov, M., et al. 2003. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull. Exp. Biol. Med., 136 (6), 585–587.
Shevtsov, V., et al. 2003. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine, 10 (2-3), 95–105.
[No author listed.] 2002. Rhodiola rosea. Monograph. Altern. Med. Rev., 7 (5), 421–423.
Brown, R., et al. 2002. Rhodiola rosea: A phytomedicinal overview. HerbalGram, J. Am. Bot. Counc., 56, 40-52.
Darbinyan, V., et al. 2000. Rhodiola rosea in stress-induced fatigue — a double-blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine, 7 (5), 365–371.
Spasov, A., et al. 2000. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-% extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine, 7 (2), 85–89.
Wing, S., et al. 2003. Lack of effect of Rhodiola or oxygenated water supplementation on hypoxemia and oxidative stress. Wilderness Environ. Med., 14 (1), 9–16.
Ha, Z., et al. 2002. [The effect of Rhodiola and acetazolamide on the sleep architecture and blood oxygen saturation in men living at high altitude.] Zhonghua Jie He He Hu Xi Za Zhi, 25 (9), 527–530.
Azizov, A., & Seifulla, R. 1998. The effect of elton, leveton, fitoton and adapton on the work capacity of experimental animals. Eksp. Klin. Farmakol., 61 (3), 61–63.
Maimeskulova, L., et al. 1997. The participation of the mu-, delta- and kappa-opioid receptors in the realization of the anti-arrhythmia effect of Rhodiola rosea. Eksp. Klin. Farmakol., 60 (1), 38–39.
Maslova, L., et al. 1994. The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress. Eksp. Klin. Farmakol., 57 (6), 61–63.
Lishmanov, I., et al. 1993. The anti-arrhythmia effect of Rhodiola rosea and its possible mechanism. Biull. Eksp. Biol. Med., 116 (8), 175–176.
Lishmanov, I., et al. 1987. Plasma beta-endorphin and stress hormones in stress and adaptation. Biull. Eksp. Biol. Med., 103 (4), 422–424.
Stancheva, S., & Mosharrof, A. 1987. Effect of the extract of Rhodiola rosea L. on the content of the brain biogenic monamines. Med. Physiol., 40, 85–87.
Petkov, V., et al. 1986. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory. Acta Physiol. Pharmacol. Bulg., 12, 3–16.

Schisandra

Park JY, Kim KH. A randomized, double-blind, placebo-controlled trial of Schisandra chinensis for menopausal symptoms. Climacteric. 2016 Dec;19(6):574-580. Epub 2016 Oct 20. PubMed PMID: 27763802.
Song MY, Wang JH, Eom T, Kim H. Schisandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study. Nutr Res. 2015 Aug;35(8):655-63. doi: 10.1016/j.nutres.2015.05.001. Epub 2015 May 14. PubMed PMID: 26048342.
Chun JN, Cho M, So I, Jeon JH. The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms. Fitoterapia. 2014 Sep;97:224-33. doi: 10.1016/j.fitote.2014.06.014. Epub 2014 Jun 27. Review. PubMed PMID: 24976588.
Koncic MZ, Tomczyk M. New insights into dietary supplements used in sport: active substances, pharmacological and side effects. Curr Drug Targets. 2013 Aug;14(9):1079-92. Review. PubMed PMID: 23574283.
Chiu HF, Chen TY, Tzeng YT, Wang CK. Improvement of liver function in humans using a mixture of schisandra fruit extract and sesamin. Phytother Res. 2013 Mar;27(3):368-73. doi: 10.1002/ptr.4702. Epub 2012 May 21. PubMed PMID: 22610748.
Panossian AG. Adaptogens in mental and behavioral disorders. Psychiatr Clin North Am. 2013 Mar;36(1):49-64. doi: 10.1016/j.psc.2012.12.005. Review. PubMed PMID: 23538076.
Gurley BJ. Pharmacokinetic herb-drug interactions (part 1): origins, mechanisms, and the impact of botanical dietary supplements. Planta Med. 2012 Sep;78(13):1478-89. doi: 10.1055/s-0031-1298273. Epub 2012 Feb 9. Review. PubMed PMID: 22322396.
Gurley BJ, Fifer EK, Gardner Z. Pharmacokinetic herb-drug interactions (part 2): drug interactions involving popular botanical dietary supplements and their clinical relevance. Planta Med. 2012 Sep;78(13):1490-514. doi: 10.1055/s-0031-1298331. Epub 2012 May 7. Review. PubMed PMID: 22565299.
Ciumasu-Rîmbu M, Popa L, Vulpoi C. Neuropeptide Y stimulation as primary target for preventive measures of maladaptative cardiovascular reactions in occupational chronic stress exposure. Rev Med Chir Soc Med Nat Iasi. 2012 Jul-Sep;116(3):790-3. PubMed PMID: 23272529.
Chan SW. Panax ginseng, Rhodiola rosea and Schisandra chinensis. Int J Food Sci Nutr. 2012 Mar;63 Suppl 1:75-81. doi: 10.3109/09637486.2011.627840. Epub 2011 Nov 1. Review. PubMed PMID: 22039930.
Chien CF, Wu YT, Tsai TH. Biological analysis of herbal medicines used for the treatment of liver diseases. Biomed Chromatogr. 2011 Jan;25(1-2):21-38. doi: 10.1002/bmc.1568. Review. PubMed PMID: 21204110.
Aslanyan G, Amroyan E, Gabrielyan E, Nylander M, Wikman G, Panossian A. Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions. Phytomedicine. 2010 Jun;17(7):494-9. doi: 10.1016/j.phymed.2010.02.005. Epub 2010 Apr 5. PubMed PMID: 20374974.
Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009 Sep;4(3):198-219. Epub 2009 Sep 1. Review. PubMed PMID: 19500070.
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Greenlee H, Atkinson C, Stanczyk FZ, Lampe JW. A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1601-9. PubMed PMID: 17684134.
Panossian A, Wagner H. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res. 2005 Oct;19(10):819-38. Review. PubMed PMID: 16261511.

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