Chronic inflammation happens as a result of the body’s
natural healing process of inflammation turning harmful when it continues long after
the original response was first needed. While it’s a relatively complicated process,
inflammation becomes “chronic” if your internal “emergency alarm” fails to shut
off when it should. This ends up allowing chronic inflammation to destroy healthy
tissue and create related symptoms.
More and more research continues to come out about the role of chronic inflammation
in the development of many diseases and cancers. I make a point to talk with all
of my patients about what chronic inflammation is so they can reduce their risk
for developing it.
Even if you’re already experiencing the warning signs of chronic inflammation, you
can still take effective steps to stop it in its tracks and you can start today.
When is inflammation harmful?
You’ve likely experienced acute inflammation with the heat of a fever, the swelling
of an injured knee and the redness of a newly-formed cut. This healthy inflammation
is an immune response that’s triggered when your body is injured, exposed to chemicals
and toxins, or invaded by bacteria, viruses or parasites.
Acute inflammation is a short-term, necessary function of the body. During a healthy
immune response, the body floods the attacked or wounded region with immune cells,
nutrients and molecules that destroy the intruder and damaged tissues. This process
creates a protective wall of defense and can occur in any part of your body – from
bones to blood vessels.
But this responsive process is only meant to be a short burst of powerful destruction.
Once the trauma goes away, inflammatory cells and molecules are supposed to recede
so the healing process can begin.
Chronic inflammation is an ongoing, destructive process. When inflammation doesn’t
turn off like it should, it turns harmful. Chronic inflammation is damaging because
it acts like a slow-burning fire, continuing to stimulate pro-inflammatory immune
cells that attack healthy areas of your body.
Chronic inflammation can occur everywhere in the body, and plenty of research indicates
that it is a common trigger for and contributor to multiple chronic diseases. For
example, excess immune cells and their signaling molecules circulating in your system
can damage blood vessel linings (in atherosclerosis), pancreatic tissue (in diabetes)
and joint tissue (in arthritis).
Symptoms of chronic inflammation
- Body aches and pain
- Depression and anxiety
- Gastrointestinal issues
- Frequent infections
- Dry eyes
- Shortness of breath
- Skin outbreaks
- Weight gain/obesity
What are the symptoms of chronic inflammation?
Chronic inflammation generates a wide range of symptoms. In my practice, the most
common symptoms I see are:
- Pain: generalized pain, in muscles and joints with
associated intermittent swelling and stiffness. Usually dull and achy in nature.
- Fatigue: fatigue is constant, with associated insomnia
or poor quality sleep.
- Depression and anxiety: inflammatory cells and molecules
within the central nervous system can disrupt the metabolism of mood-related neurotransmitters
such as serotonin. It’s thought that this imbalance can potentially lead to mood
disorders such as depression and anxiety.
- Gastrointestinal issues: abdominal pain, constipation,
diarrhea, gas and acid reflux.
As these symptoms can overlap with other health issues, be sure to talk with your
doctor to see if your symptoms stem from chronic inflammation.
Symptoms of chronic inflammation may spread slowly, eventually leading to a serious
metabolic breakdown, and chronic disease. Chronic inflammation can have vast implications
for long-term health. The best way to understand its effects is to look at a known
inflammatory disease such as rheumatoid arthritis. I have a young patient with this
painful autoimmune disease, and she has all the symptoms of severe chronic inflammation:
chronic pain, fatigue, obesity, memory loss, insomnia and more. For her, the solution
is to shut down her immune system to control her symptoms. For someone like you,
the goal is probably to stop chronic inflammation trigger before it causes illness.
What’s at the root of chronic inflammation?
An imbalanced immune system contributes to chronic inflammation by sending your
body misdirected signals that inflammation is still needed long after the initial
reason has passed.
Studies have demonstrated that women with chronic inflammation have increased levels
of certain pro-inflammatory markers such as C-reactive protein (CRP), IFN-gamma,
IL-1, IL-6, and TNF-alpha. While these same markers are also elevated during an
acute reaction, if the immune system is well-balanced, the inflammatory reaction
will turn off as it should — when the job is done. If the inflammation continues,
your body will stay constantly on the defensive and that can lead to damaging effects
on your health:
- Inflammation drains your body’s energy and resources and leaves it vulnerable.
- Inflammatory cells are very powerful (this helps get rid of invaders before they
can do harm) — and produce a constant, low-grade flow of strong inflammatory markers
into the blood stream that can cause damage with time.
- Once the balance is disrupted, the immune system’s inflammatory hyperactivity can
self-perpetuate and quickly spiral into disease.
Are there tests to identify chronic inflammation?
Unfortunately there isn’t a highly effective laboratory measure to assess patients
for chronic inflammation. It really is a diagnosis by process of elimination – which
means other possibilities must be ruled out.
One test measures CRP protein in your blood. Higher levels indicate inflammation
in your system. But while an elevated CRP indicates that inflammation is happening,
it can’t tell the difference between acute inflammation and chronic inflammation.
It also can’t measure the extent of inflammation going on in your system.
More research is showing marked elevation of major inflammatory markers with diseases
we suspect are due to chronic inflammation. For example, women with type II diabetes
have been found to have elevated CRP and IL-6. It is likely we will have a laboratory
measure for chronic inflammation in the future as we further investigate these chronic
How do I know if I have chronic inflammation?
So how do you tell if you are suffering from chronic inflammation? Take a look at
the following factors to see what you should investigate further:
- Learn your genetic risk factors. Major risk factors
for chronic inflammation include a family history of autoimmune issues or chronic
disease like heart disease, Alzheimer’s, and cancer. This is probably your most
important assessment because it tells you how you are genetically pre-disposed to
manage inflammatory processes.
- Look at your symptoms. If the symptoms in the lists
above sound familiar, you may want to discuss chronic inflammation with your healthcare
- Know what has been ruled out. Depending on your symptoms,
your healthcare practitioner may want to do tests to rule out other possible causes
for your symptoms such as more serious autoimmune processes like rheumatoid arthritis.
- Examine your lifestyle: Obesity, poor diet and low-activity
level are all major risk factors for inflammation. You can change these using our
steps for living
an anti-inflammatory lifestyle.
Are aspirin and NSAIDs helpful for chronic inflammation?
I’m sometimes asked if women should routinely take aspirin or NSAIDs (nonsteroidal
anti-inflammatory drugs) like Motrin and Aleve to stop inflammation. In my opinion,
they aren’t helpful for chronic inflammation because they don’t address the root
causes of inflammation – and can even lead to additional health risks.
Ongoing use of even mild anti-inflammatory drugs can lead to digestive issues, ulcers,
increased bleeding, and kidney problems. The United States Preventive Services Task
Force currently recommends the regular use of aspirin for the primary prevention
of cardiovascular disease and colorectal cancer in women ages 50-59 with high risk
for cardiovascular issues. For women older or younger than this age, aspirin use
is dependent on a risk-benefit ratio. Since aspirin consumption does have its own
set of risks, discuss your risks with your doctor before starting an aspirin protocol.
In addition, NSAIDs disrupt the production of prostaglandins, which are needed to
regulate inflammation, constrict or dilate vessels and much more. Corticosteroids
like prednisone, COX-2 inhibitors like Vioxx and Celebrex, and antihistamines each
shut down a different inflammatory mechanism, leading to further long-term risks
in the body.
How to really reduce inflammation
If you think you are at risk for chronic inflammation, you can reduce inflammation
with a natural approach – and it’s much easier than you might think. See how you
can get started right now with
7 steps to an anti-inflammatory lifestyle.
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