Delivery methods:
Topical/Transdermal Oral Transvaginal

Estrogens: E1 = estrone; E2 = estradiol; E3 = estriol

Brand-name choices available through regular pharmacies

Most of these products provide only E2 (estradiol)

The exception is Bezwecken E3 vaginal suppositories, which deliver 1 mg estriol per suppository

Lotion
• Estrasorb

Gels
• Divigel
• Elestrin
• EstroGel

Spray
• Evamist

Patches
• Climara
• Vivelle
• Alora
• Menostar

Cream
• Estrace

Vaginal rings
• Estring (90-day vaginal ring – provides local delivery to vaginal tissues only)
• Femring (90-day vaginal ring – provides systemic delivery)

Vaginal suppositories
• Vagifem vaginal insert
• Bezwecken E3 vaginal suppository (1 mg estriol)

Compounded bioidentical hormones available through compounding pharmacies

Primarily estradiol (E2), but depending upon a woman’s hormone panel, E1, E3, or other hormones may also be included

• Liquid lotion in dropper bottle

• Sublingual (under the tongue) troches (tro’-keez)
• “Melts”
• Solution in dropper bottle

• Estriol vaginal cream in a pH-balanced base, concentrations of 0.6 mg/g or 0.8 mg/g

P = Progesterone (P)

Brand-name choice available through regular pharmacies

Capsule:
• Prometrium (micronized progesterone in peanut oil)

Capsule can be placed in vagina (speak with your practitioner about this first)

Compounded bioidentical hormones available through compounding pharmacies

• Compounded topically-applied cream or lotion

• Capsules (micronized progesterone, usually in olive oil)
• Troches (lozenges)
• “Melts”
• Solution in dropper bottle

T = Testosterone

Compounded bioidentical hormones available through compounding pharmacies

• Compounded topically-applied cream, gel, or lotion

• Solution in dropper bottle
• “Melts”
• Troches (lozenges)
• Tablets of varying doses

Others

DHEA

A hormone precursor, sometimes prescribed in support of adrenal function

• Compounded topically-applied cream or lotion

• Solution in dropper bottle
• “Melts”
• Tablets

Pregnenolone
Cortisol
Thyroid hormones (T3 and T4)

Most women don’t think of these as forms of hormone replacement therapy, but prescriptions are sometimes individualized and compounded for women. In particular, many women do well on natural forms of thyroid hormone replacement.

• Solution in dropper bottle
• Tablets
• Capsules