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Super Wellness Combo

Super Wellness Combo

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Super Wellness Combo

Achieving and maintaining good health is easier with our Super Wellness Combo because it includes two of the most important supplements you should add to your daily regimen. Super Antioxidant is your best ally in the fight against free-radicals and the damage they can create in your body. Free radicals are generated by everything from processed foods to smoking to environmental toxins. Since most experts agree that true health begins with good digestion function, give your body the probiotic dosage it needs every day with our Super Biotic. Probiotics are live “friendly” bacteria that promote a healthy gastrointestinal tract, relieve digestive symptoms and bolster immune health.

What you get with the Combo:

Super Antioxidant — formulated to help protect your body from the effects of oxidative stress by working to neutralize free radicals, this powerful antioxidant delivers additional amounts of healing agents for healthy joint function.

Super Antioxidant includes:

  • Meriva® Curcumin Phytosome — this patented formulation of curcumin helps counter the negative effects of oxidative stress and includes a special form of phosphatidylcholine with superior bioavailability to allow more curcumin to reach the cells.
  • Lycopene — this powerful carotenoid antioxidant is found in tomatoes and other fruits and vegetables. It supports healthy bone mineral density and a reduction in oxidative stress while helping to reduce bone resorption markers that indicate bone breakdown.
  • Vitamin C — this buffered mineral-ascorbate form of the most well-known natural antioxidant is gentle on the stomach, and involved in collagen formation in your bones, cartilage, blood vessels and connective tissues.

Super Biotic — formulated to help soothe and digestive symptoms and normalize gut function, this exclusive probiotic can also boost your natural immune function and support healthy brain function and mental health.

Super Biotic includes:

  • Lactobacilli — as L. Acidophilus, L. Rhamnosus, L. Lactisand L. Gasseri , wards off the bacteria and organisms that contribute to digestive or vaginal imbalance.
  • Bifidobacterium — as B. Lactis, B. Longum and B. Bifidum, promotes colon health and enhances cellular immunity.
  • Streptococcus thermophilus — promotes regularity and helps break down lactose.

How to use:

For Super Antioxidant — take one vegetarian capsule twice a day, once with breakfast and another with lunch or dinner.

For Super Biotic — take just one capsule every day with breakfast or lunch.

We recommend using both formulas for at least 30-60 days before evaluating your results so you have enough time to allow your body to heal and reset digestively. For best results, it’s essential to use both products together regularly every day as directed.

This Super Wellness Combo is intended to last a full 30 days.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Super Wellness Combo Ingredients

Product References

Super Antioxidant

Our Super Antioxidant is formulated to be complete, natural, bioavailable and manufactured to pharmaceutical standards.

The following articles and studies, arranged alphabetically, represent a sampling of the research on the constituents of Super Antioxidant.

Vitamin C (Calcium ascorbate)

Anderson, P. A., et al. 2012. Correlations of capture, transport, and nutrition with spinal deformaties in sandtiger sharks, Carcharias Taurus, in public aquaria. J Zoo Wildl Med. 43(4): 750-8. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23272341 (accessed 2/6/2013).

Ceriello, A., et al. 2012. Evidence that hyperglycemia after recovery from hypoglycemia worsens endothelial function and increases oxidative stress and inflammation in healthy control subjects and subjects with type 1 diabetes. Diabetes. 61 (11): 2993-7. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22891214 (accessed 2/7/2013)

Cha, J., et al. 2013. Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C-deficient mice. Int J Oncol. 42(1): 55-64. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23175106 (accessed 2/6/2013).

De Pablo, P., et al. 2007. Antioxidants and other novel cardiovascular risk factors in subjects with rheumatoid arthritis in a large population sample. Arthritis Rheum., 57 (6), 953–962. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/17665477 (accessed 2/4/2013).

Dennehy, C., & Tsourounis, C. 2010. A review of select vitamins and minerals used by postmenopausal women. Maturitas, 66 (4), 370–380. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20580500 (accessed 2/6/2013).

Farombi, E., & Onyema, O. 2006. Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: Modulatory role of vitamin C, vitamin E and quercetin. Hum. Exp. Toxicol., 25 (5), 251–259. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16758767 (accessed 2/6/2013).

Frei, B., et al. 2012. Authors’ perspective: What is the optimum intake of vitamin C in humans? Crit Rev Food Sci Nutr. 52(9): 815-29. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22698272 (accessed 2/7/2013).

Gabbay, K., et al. 2010. Ascorbate synthesis pathway: Dual role of ascorbate in bone homeostasis. J. Biol. Chem., 285 (25), 19510–19520. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20410296 (accessed 2/6/2013).

Gunes, T., et al. a-tocopherol and ascorbic acid in early postoperative period of cardiopulmonary bypass. J Cardiovasc Med (Hagerstown). 13(11): 691-9. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22885531 (accessed 2/7/2013).

Harikrishnan, R., et al. 2013. Protective effect of ascorbic acid against ethanol-induced reproductive toxicity in male guinea pigs. Br J Nutr. 21: 1-10 [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23336340 (accessed 2/6/2013).

Hie, M., & Tsukamoto, I. 2010. Vitamin C-deficiency stimulates osteoclastogenesis with an increase in RANK expression. J. Nutr. Biochem. 22(2): 164-71. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20444587 (accessed 2/6/2013).

Jelodar, G., et al. 2013. The prophylactic effect of vitamin C on induced oxidative stress in rat testis following exposure to 900 MHz radio frequency wave generated by a BTS antenna model. Electromagn Biol Med. [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23323690 (accessed 2/6/2013).

Lee, C. H., et al. 2013. Involvement of Mitochondrial DNA Damage Elicited by Oxidative Stress in the Arsenical Skin Cancers. J Invest Dermatol. [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23370535 (accessed 2/6/2013).

Lee, T. H., et al. 2013. The use of lyophilized plasma in severe multi-injury pig model. Transfusion. 53 Suppl 1:72S-9S. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23301977 (accessed 2/7/2013).

Maggio, D., et al. 2003. Marked decrease in plasma antioxidants in aged osteoporotic women: Results of a cross-sectional study. J. Clin. Endocrin. Metab., 88 (4), 1523–1527. URL: http://jcem.endojournals.org/cgi/content/full/88/4/1523 (accessed 2/6/2013).

Maïmoun, L., et al. 2008. Effect of antioxidants and exercise on bone metabolism. J. Sports Sci., 26 (3), 251–258. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18074298 (accessed 2/6/2013).

Massé, P., et al. 2008. Cardiovascular disease-risk factors in middle-aged osteopaenic women treated with calcium alone or combined to three nutrients essential to artery and bone collagen. J. Hum. Nutr. Diet., 21 (2), 117–128. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18339052 (accessed 2/6/2013).

McAlindon, T., et al. 1996. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis. Rheum., 39 (4), 648–656. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/8630116 (accessed 2/6/2013).

Mikirova, N., et al. 2012. Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Transl Med. 10: 189. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22963460 (accessed 2/7/2013).

Morton, D. 2001. Vitamin C supplement use and bone mineral density in postmenopausal women. J. Bone Miner. Res., 16 (1), 135–140. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11149477 (accessed 2/6/2013).

Neto, A., et al. 2010. Profiling the changes in signaling pathways in ascorbic acid/beta-glycerophosphate-induced osteoblastic differentiation. J. Cell. Biochem. 112(1): 71-7. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20626033 (accessed 2/6/2013).

de Oliveira, B. F., et al. 2012. Ascorbic acid, alpha-tocopherol, and beta-carotene reduce oxidative stress and proinflammatory cytokines in mononuclear cells of Alzheimer’s disease patients. Nutr Neurosci. [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22710805 (accessed 2/7/2013).

Ruiz–Ramos, M., et al. 2010. Supplementation of ascorbic acid and alpha-tocopherol is useful to preventing bone loss linked to oxidative stress in elderly. J. Nutr. Health Aging, 14 (6), 467–472. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20617290 (accessed 2/6/2013).

Sahni, S., et al. 2008. High vitamin C intake is associated with lower 4-year bone loss in elderly men. J. Nutr., 138 (10), 1931–1938. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18806103 (accessed 2/6/2013).

Stabler, T., & Kraus, V. 2003. Ascorbic acid accumulates in cartilage in vivo. Clin. Chim. Acta, 334, 157–62. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12867287 (accessed 2/6/2013).

Temu, T., et al. 2010. The mechanism of ascorbic acid-induced differentiation of ATDC5 chondrogenic cells. Am. J. Physiol. Endocrinol. Metab., 299 (2), E325–334. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20530736 (accessed 2/6/2013).

Zanoni, J. N., et al. 2013. Histological evaluation of the periodontal ligament from aged wistar rats supplemented with ascorbic acid. An Acad Bras Cienc. [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23348562 (accessed 2/6/2013).

Meriva Curcumin Phytosome
(Curcuma longa, Phosphatidylcholine)

Ak, T. & Gülçin, I. 2008. Antioxidant and radical scavenging properties of curcumin. Chemico-biological Interactions. 174(1): 24-37. URL (abstract): DOI:10.1016/j.cbi.2008.05.003 (accessed 12/18/2012).

Allegri, P., et al. 2010. Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clin Ophthalmol. 4, 1201-1206. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964958/ (accessed 11/27/2012).

Appendino, G., et al. 2011. Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study. Panminerva Med. 53(3 Suppl 1), 43-9. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22108476 (accessed 11/26/2012)

Belcaro, G., et al. 2010. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 15 (4), 337-44. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21194249 (accessed 11/27/2012)

Bradley, JR. 2008. TNF-mediated inflammatory disease. J Pathol. 214 (2): 149-60. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18161752 (accessed 12/18/2012)

Belcaro, G., et al. 2010. Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med. 52 (2 Suppl 1), 55-62. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20657536 (accessed 11/27/20012)

Chandran, B. & Goel, A. 2012. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res.26(11):1719-25. doi: 10.1002/ptr.4639 (accessed 12/18/2012).

Cuomo, J., et al. 2011. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod. , 74(4):664-9. Epub 2011 Mar 17. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21413691 (accessed 11/26/2012)

Gupta, N.K. & Dixit, V.K. 2011. Bioavailability enhancement of curcumin by complexation with phosphatidyl choline. J Pharm Sci. 100(5): 1987-95. URL: doi: 10.1002/jps.22393 (accessed 12/20/2012).

Heeba, G. H., et al. 2012. Anti-inflammatory potential of curcumin and quercetin in rats: Role of oxidative stress, heme oxygenase-1 and TBF- a. Toxicol Ind Health. Sept 28 (Epub ahead of print). URL: http://www.ncbi.nlm.nih.gov/pubmed/23024111 (accessed 12/18/2012).

Huang, G., et al. 2012. Curcumin Protects Against Collagen-Induced Arthritis via Suppression of BAFF Production. J Clin Immunol. November 27 (Epub ahead of print). URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23184090 (accessed 12/18/2012).

Ibrahim, A., et al. 2012. Effect of curcumin and Meriva on the lung metastasis of murine mammary gland adenocarcinoma. In Vivo. July-Aug. 24 (4), 401-8. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20668306 (accessed 11/27/2012)

Innes, J.F., et al. 2003. Randomised, double-blind, placebo-controlled parallel group study of P54FP for the treatment of dogs with osteoarthritis. Vet Rec. 152 (15): 547-60. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12723628 (accessed 12/18/2012).

Iqbal, M., et al. 2003. Dietary Supplementation of Curcumin Enhances Antioxidant and Phase II Metabolizing Enzymes in ddY Male Mice: Possible Role in Protection against Chemical Carcinogenesis and Toxicity. Pharmacology & Toxicology. 92: 33-38. URL: http://onlinelibrary.wiley.com/doi/10.1034/j.1600-0773.2003.920106.x/pdf (accessed 1/16/2012)

Jaco A., et al. 2007. Mechanism of the Anti-Inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR Res. 2007: 89369. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18274631 (accessed 11/27/2012)

Khanna, S., et al. 2009. Neuroprotective and anti-inflammatory properties of a novel demethylated curcuminoid. Antioxidants & Redox Signaling. 11(3): 449-468. URL (abstract): DOI:10.1089/ars.2008.2230 (accesed 12/18/2012).

Kuptniratsaikul V., et al. 2009. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J Altern Complement Med. 15(8):891-7. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19678780 (accessed 12/18/2012).

Lavrovsky, Y., et al. 2000. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol. Aug, 35 (5):521-32. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/10978675 (accessed 12/18/2012).

Liu, A., et al. 2006. Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcumin. J Pharm Biomed Anal. 40(3): 720-7. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16316738 (accessed 12/20/2012).

Maiti, K., et al. 2007. Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats. Int J Pharm. 330(1-2): 155-63. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/17112692 (accessed 12/20/2012).

Marczylo, T.H., et al. 2007. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylecholine. Cancer Chemother Pharmacol. 60 (2), 171-7. Epub 2006 Oct 19. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/17051370 (accessed 11/27/2012)

Mazzolani, F. 2012. Pilot study of oral administration of a curcumin-phospholipid formulation for treatment of central serous chorioretinopathy. Clin Ophthalmol. 6, 801-6. Epub May 28, 2012. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22701080 (accessed 11/26/2012).

Mobasheri, A., et al. 2012. Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutrceuticals for Joint Health. Int J Mol Sci. 13(4): 4202-4232. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344210/ (accessed 12/20/2012).

Obrenovich, M.E., et al. 2010. The role of polyphenolic antioxidants in health, disease, and aging. Rejuvenation Research. 13(6): 631-643. URL (abstract): DOI:10.1089/rej.2010.1043 (accessed 12/18/2012).

Phan, T.-T., et al. 2001. Protective Effects of Curcumin against Oxidative Damage on Skin Cells In Vitro: Its Implications for Would Healing. Journal of Trauma-Injury Infection & Critical Care. 51 (5): 927-931. URL (abstract): http://journals.lww.com/jtrauma/Abstract/2001/11000/Protective_Effects_of_Curcumin_against_Oxidative.17.aspx (accessed 1/16/2013).

Popa, C., et al. 2007. The role of TNF-a in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. The Journal or Lipid Research. 48 (751-762). URL: doi: 10.1194/jlr.R600021-JLR200 (accessed 12/18/2012).

Priyadarsini, K. I., et al. 2003. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radical Biology and Medicine. 35(5): 475-484. URL (abstract): http://dx.doi.org/10.1016/S0891-5849(03)00325-3 (accessed 12/18/2012).

Ruby, A.J., et al. 1995. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Letters. 94(1): 79-83. URL (abstract): http://dx.doi.org/10.1016/0304-3835(95)03827-J (accessed 12/18/2012).

Serpe, R., et al. 2011. Cucuma longa extract is effective in reducing blood levels of reactive oxygen species (ROS) and increasing antioxidant enzyme glutathione peroxidase (GPx) in patients with cancer-related cachexia and oxidative stress. Abstracts of the 6th Cachexia Conference, Milan, Italy, December 8-10, 2011. J Cachexia Sarcopenia Muscle. 2(4), 209-61. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222823/ (accessed 11/27/2012)

Shen, C.L., et al. 2012. Dietary polyphenols and mechanisms of osteoarthritis. J Nutr Biochem. 23(11): 1367 – 77. URL (abstract): i: 10.1016/j.jnutbio.2012.04.001 (accessed 12/18/2012).

Shehzad, A., et al. 2012. Curcumin in inflammatory disease. BioFactors. Epub ahead of print. doi: 10.1002/biof.1066. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23281076 (accessed 1/16/2013)

Shishodia S, Sethi G, Aggarwal BB. 2005. Curcumin: getting back to the roots. Ann N Y Acad Sci. Nov. 1056 (206-17). URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed?term=Curcumin%3A%20getting%20back%20to%20the%20roots%5BTitle%5D (accessed 12/18/2012).

Wolkmer, P., et al. 2012. Pre-treatment with curcumin modulates acetylcholinesterase activity and proinflammatory cytokines in rats infected with Trypanosoma evansi. Parasitol Int. Nov 29 (Epub ahead of print). URL: doi: 10.1016/j.parint.2012.11.004. (accessed 12/18/2012).

Lycopene

Aydin, S. et al. 2012. Antioxidant and antigenotoxic effects of lycopene in obstructive jaundice. J Surg Res. 2012 Nov 7 [Epub ahead of print]. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23154037 (accessed 2/5/2013).

De Pablo, P., et al. 2007. Antioxidants and other novel cardiovascular risk factors in subjects with rheumatoid arthritis in a large population sample. Arthritis Rheum., 57 (6), 953–962. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/17665477 (accessed 2/4/2013).

Fujita, K., et al. 2013. Lycopene inhibits ischemia/reperfusion-induced neuronal apoptosis in gerbil hippocampal tissue. Neurochem res. 2013 Jan 8 [Epub ahead of print]. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23296626 (accessed 2/5/2013).

Garrido, M., et al. 2012. A lycopene-enriched virgin olive oil enhances antioxidant status in humans. J Sci Food Agric. 2012 Oct 26 [Epub ahead of print]. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23225211 (accessed 2/5/2013).

Grainger, E. M., et al. 2008. A combination of tomato and soy products for men with recurring prostate cancer and rising prostate specific antigen. Nutr Cancer. 60(2): 145-54. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18444145 (accessed 2/5/2013).

Hsiao, G., et al. 2005. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J. Lab. Clin. Med., 146 (4), 216–226. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16194683 (accessed 2/4/2012).

Kim, G., et al. 2004. Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB. Immunology, 113 (2), 203–211. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/15379981 (accessed 4/2/2013).

Kremore, T.V., et al. 2012. Evaluation of the effect of newer antioxidant lycopene in the treatement of oral submucous fibrosis. Indian J Dent Res. 23 (4): 524-8. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23257490 (accessed 4/5/2013).

Kim, L., et al. 2003. Lycopene II — effect on osteoblasts: The carotenoid lycopene stimulates cell proliferation and alkaline phosphatase activity of SaOS-2 cells. J. Med. Food, 6 (2), 79–86. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12935317 (accessed 2/4/2013).

Liang, H., et al. 2012. Lycopene effects on serum mineral elements and bone strength in rats. Molecules. 17 (6): 7093-102. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22728373 (accessed 1/16/2013).

Mackinnon, E. S., et al. 2011. Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women. J Nutr Health Aging. 15(2): 133-8. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21365167 (accessed 1/16/2013).

Mackinnon, E. S., et al. 2011. Supplementation with antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telepeptide of type 1 collagen in postmenopausal women. Osteoporos Int.22 (4): 1091-101. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20552330 (accessed 1/16/2013).

Marcotorchino, J., et al. 2012. Lycopene attenuates LPS-induced TNF-a secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media. Mol Nutr Food Res. 56 (5): 725-32. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22648619 (accessed 2/4/2013).

Pattison, D., et al. 2005. Dietary beta-cryptoxanthin and inflammatory polyarthritis: Results from a population-based prospective study. Am. J. Clin. Nutr., 82 (2), 451–455. URL: http://www.ajcn.org/cgi/content/full/82/2/451 (accessed 2/4/2013).

Quilliot, D., et al. 2011. Carotenoid deficiency in chronic pancreatitis: the effect of an increase in tomato consumption. Eur J Clin Nutr. 65(2): 262-8. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21119697 (accessed 2/5/2013).

Rao, L., et al. 2007. Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women. Osteoporos. Int., 18 (1), 109–115. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16941193 (accessed 2/4/2013).

Rao, L., et al. 2003. Lycopene I — effect on osteoclasts: Lycopene inhibits basal and parathyroid hormone-stimulated osteoclast formation and mineral resorption mediated by reactive oxygen species in rat bone marrow cultures. J. Med. Food., 6 (2), 69–78. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12935316 (accessed 2/4/2013).

Rauscher, R., et al. 1998. In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids. Mutat. Res., 413 (2), 129–142. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/9639691 (accessed 2/4/2013).

Renju, G.l., et al. 2012. Anti-inflammatory activity of lycopene isolated from Chlorella marina on type II collagen-induced arthritis in Sprague Dawley rats. Immunopharmacol Immunotoxicol. 2012 Dec 14 (Epub ahead of print) URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23237458 (accessed 2/4/2013).

Sahni, S., et al. 2009. Inverse association of carotenoid intakes with 4–y change in bone mineral density in elderly men and women: The Framingham Osteoporosis Study. Am. J. Clin. Nutr., 89 (1), 416–424. URL http://www.ncbi.nlm.nih.gov/pubmed/19056581 (accessed 2/4/2013).

Sahni, S., et al. 2009. Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: A 17-year follow-up from the Framingham Osteoporosis Study. J. Bone Miner. Res., 24 (6), 1086–1094. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683648/?tool=pubmed (accessed 2/4/2013).

Shidfar, F., et al. 2012. Lycopene an adjunctive therapy for Helicobacter pylori eradication: a quasi-control trial. J Complement Integr Med. 9:Article 14. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22850072 (accessed).

Shen, C. L., et al. 2012. Fruits and dietary phytochemicals in bone protection. Nutr Res. 32 (12): 897-910. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/23244535 (accessed 1/16/2013).

Thies, F., et al. 2012. Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, disease-free, middle-aged adults: a randomized controlled trial. Am J Clin Nutr. 95(5): 1013-22. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22492370 (Accessed 2/5/2013).

Van Breemen, R. B., et al. 2002. Liquid chromatography-mass spectrometry of cis- and all-trans-lycopene in human serum and prostate tissue after dietary supplementation with tomato sauce. J Agric Food Chem. 50(8): 2214-9. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11929273 (accessed 2/5/2013).

Wattanapenpaiboon, N., et al. 2003. Dietary carotenoid intake as a predictor of bone mineral density. Asia Pac. J. Clin. Nutr., 12 (4), 467–473. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/14672872 (accessed 2/4/2013).

Xaplanteris, P., et al. 2012. Tomato paste supplementation improves endothelial dynamics and reduces plasma total oxidative status in healthy subjects. Nutr Res. 32 (5): 390-4. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/22652379 (accessed 2/4/2013).

Yang, Z., et al. 2008. Serum carotenoid concentrations in postmenopausal women from the United States with and without osteoporosis. Int. J. Vitam. Nutr. Res., 78 (3), 105–111. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19003732 (accessed 2/4/2013).

Zhao, X., et al. 2006. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. Am J Clin Nutr. 93(1): 163-9. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16400064 (accessed 2/5/2013).

Super Biotic

Our Super Biotic is doctor-formulated to be complete, natural, bioavailable, and manufactured to pharmaceutical standards.

The following articles and studies, arranged in order of recency, provide information concerning the clinical basis for using Super Biotic.

Fujimori, S., et al. 2007. High dose probiotic and prebiotic cotherapy for remission induction of active Crohn’s disease. J. Gastroenterol. Hepatol., 22 (8), 1199–1204. URL (abstract): http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=ShowDetailView&TermToSearch=17688660 (accessed 10.24.2007).

Boyle, R., et al. 2006. Probiotic use in clinical practice: What are the risks? Am. J. Clin. Nutr., 83, 1256–1264. URL (full text): http://www.ajcn.org/cgi/content/full/83/6/1256 (accessed 10.24.2007).

Falagas, M. et al. 2006. Probiotics for prevention of recurrent urinary tract infections in women: A review of the evidence from microbiological and clinical studies. Drugs, 66 (9), 1253–1261. URL (abstract): http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=ShowDetailView&TermToSearch=16827601 (accessed 10.04.2007).

Frankenfeld, C., et al. 2006. Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes. Maturitas, 53 (3), 315–324. URL (abstract): http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=ShowDetailView&TermToSearch=16019168 (accessed 10.24.2007).

Parvez, S., et al. 2006. Probiotics and their fermented food products are beneficial for health. J. Appl. Microbiol., 100, 1171–1185. URL (full text): http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1365-2672.2006.02963.x (accessed 10.24.2007).

Uehara, S., et al. 2006. A pilot study evaluating the safety and effectiveness of Lactobacillus vaginal suppositories in patients with recurrent urinary tract infection. Int. J. Antimicrob. Agents, 28, (Suppl. 1) S30–S34. URL (abstract): http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16859900> (accessed 10.04.2007).

Marshall, B. 2005. The Lasker Awards: Celebrating scientific discovery. JAMA, 294, 1420–1421.

Adolfsson, O., et al. 2004. Yogurt and gut function. Am. J. Clin. Nutr., 80, 245–256. URL (full text): http://www.ajcn.org/cgi/content/full/80/2/245 (accessed 10.24.2007).

Lin, H. 2004. Small intestinal bacterial overgrowth: A framework for understanding irritable bowel syndrome. JAMA, 292 (7), 852–858. URL (full text): http://jama.ama-assn.org/cgi/content/full/292/7/852 (accessed 10.24.2007).

Marelli, G., et al. 2004. Lactobacilli for prevention of urogenital infections: A review. Eur. Rev. Med. Pharmacol. Sci., 8 (2), 87–95. URL (abstract): http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15267122 (accessed 10.04.2007).

Wang, K-Y., et al. 2004. Effects of ingesting Lactobacilus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori. Am. J. Clin. Nutr., 80, 737–741. URL (full text): http://www.ajcn.org/cgi/content/full/80/3/737 (accessed 10.24.2007).

Halsted, C. 2003. Dietary supplements and functional foods: 2 sides of a coin? Am. J. Clin. Nutr., 77 (Suppl.), 1001S–1007S. URL (full text): http://www.ajcn.org/cgi/content/full/77/4/1001S (accessed 10.24.2007).

Fernández, M., et al. 2003. Probiotic properties of human lactobacilli strains to be used in the gastrointestinal tract. J. Appl. Microbiol., 94, 449–455. URL (abstract): http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2672.2003.01850.x (accessed 10.24.2007).

Reid, G., et al. 2003. Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: Randomized, placebo-controlled trial. FEMS Immunol. Med. Microbiol., 25 (20), 131–134. URL (abstract): http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12628548 (accessed 10.04.2007).

Reid, G., et al. 2003. Potential uses of probiotics in clinical practice. Clin. Microbiol. Rev., 16 (4), 658–672. URL: (full text): http://cmr.asm.org/cgi/content/full/16/4/658?view=long&pmid=1455729 (accessed 10.24.2007).

Duggan, C., et al. 2002. Protective nutrients and functional foods for the gastrointestinal tract. Am. J. Clin. Nutr., 75, 789–808. URL (full text): http://www.ajcn.org/cgi/content/full/75/5/789 (accessed 10.24.2007).

Ishikawa, H., et al. 2002. Randomized controlled trial of the effect of bifidobacteria-fermented milk on ulcerative colitis. J. Am. Coll. Nutr., 22 (1), 56–63. URL (full text): http://www.jacn.org/cgi/content/full/22/1/56 (accessed 10.24.2007).

Holzapfel, W., et al. 2001. Taxonomy and important features of probiotic microorganisms in food and nutrition. Am. J. Clin. Nutr., 73 (Suppl.), 365S–373S. URL (full text): http://www.ajcn.org/cgi/content/full/73/2/365S (accessed 10.24.2007).

Ishibashi, N., & Yamazaki, S. 2001. Probiotics and safety. Am. J. Clin. Nutr., 73 (Suppl.), 465S–470S. URL (full text): http://www.ajcn.org/cgi/content/full/73/2/465S (accessed 10.24.2007).

Isolauri, E., et al. 2001. Probiotics: Effects on immunity. Am. J. Clin. Nutr., 73 (Suppl.), 444S–450S. URL (full text): http://www.ajcn.org/cgi/content/full/73/2/444S (accessed 10.24.2007).

Isolauri, E. 2001. Probiotics in human disease. Am. J. Clin. Nutr., 73 (Suppl.), 1142S–1146S. URL (full text): http://www.ajcn.org/cgi/content/full/73/6/1142S (accessed 10.24.2007).

Marteau, P., et al. 2001. Protection from gastrointestinal diseases with the use of probiotics. Am. J. Clin. Nutr., 73 (Suppl.), 430S–436S. URL (full text): http://www.ajcn.org/cgi/content/full/73/2/430S (accessed 10.24.2007).

Saavedra, J. 2001. Clinical applications of probiotic agents. Am. J. Clin. Nutr., 73 (Suppl.), 1147S–1151S. URL (full text): http://www.ajcn.org/cgi/content/full/73/6/1147S (accessed 10.24.2007).

Vanderhoof, J. 2001. Probiotics: Future directions. Am. J. Clin. Nutr., 73 (Suppl.), 1152S–1155S. URL (full text): http://www.ajcn.org/cgi/content/full/73/6/1152S (accessed 10.24.2007).

Wollowski, I., et al. 2001. Protective role of probiotics and prebiotics in colon cancer. Am. J. Clin. Nutr., 73 (Suppl.), 451S–455S. URL (full text): http://www.ajcn.org/cgi/content/full/73/2/451S (accessed 10.24.2007).

Roberfroid, M. 2000. Prebiotics and probiotics: Are they functional foods? Am. J. Clin. Nutr., 71 (Suppl.), 1682S–1687S. URL (full text): http://www.ajcn.org/cgi/content/full/71/6/1682S (accessed 10.24.2007).

Collins, M., & Gibson, G. 1999. Probiotics, prebiotics, and synbiotics: Approaches for modulating the microbial ecology of the gut. Am. J. Clin. Nutr., 69 (Suppl.), 1052S–1057S. URL (full text): http://www.ajcn.org/cgi/content/full/69/5/1052S (accessed 10.24.2007).

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